Transcriptional control of central carbon metabolic flux in Bifidobacteria by two functionally similar, yet distinct LacI-type regulators.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 11 2019
28 11 2019
Historique:
received:
08
08
2019
accepted:
06
11
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
5
11
2020
Statut:
epublish
Résumé
Bifidobacteria resident in the gastrointestinal tract (GIT) are subject to constantly changing environmental conditions, which require rapid adjustments in gene expression. Here, we show that two predicted LacI-type transcription factors (TFs), designated AraQ and MalR1, are involved in regulating the central, carbohydrate-associated metabolic pathway (the so-called phosphoketolase pathway or bifid shunt) of the gut commensal Bifidobacterium breve UCC2003. These TFs appear to not only control transcription of genes involved in the bifid shunt and each other, but also seem to commonly and directly affect transcription of other TF-encoding genes, as well as genes related to uptake and metabolism of various carbohydrates. This complex and interactive network of AraQ/MalR1-mediated gene regulation provides previously unknown insights into the governance of carbon metabolism in bifidobacteria.
Identifiants
pubmed: 31780796
doi: 10.1038/s41598-019-54229-4
pii: 10.1038/s41598-019-54229-4
pmc: PMC6882875
doi:
Substances chimiques
Lac Repressors
0
Carbon
7440-44-0
Aldehyde-Lyases
EC 4.1.2.-
phosphoketolase
EC 4.1.2.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17851Références
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