Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent.
Angiotensin I
/ blood
Angiotensin II
/ pharmacology
Angiotensin-Converting Enzyme 2
Animals
Blood Pressure
/ drug effects
Carboxypeptidases
/ genetics
Male
Mice
Mice, Knockout
Peptide Fragments
/ blood
Peptidyl-Dipeptidase A
/ genetics
Prolyl Oligopeptidases
Renin-Angiotensin System
/ drug effects
Serine Endopeptidases
/ genetics
angiotensins
hypertension
renin-angiotensin system
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
4
12
2019
medline:
25
7
2020
entrez:
3
12
2019
Statut:
ppublish
Résumé
The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System encompasses 3 enzymes that form Angiotensin-(1-7) [Ang-(1-7)] directly from Ang II: ACE2 (angiotensin-converting enzyme 2), PRCP (prolylcarboxypeptidase), and POP (prolyloligopeptidase). We investigated their relative contribution to Ang-(1-7) formation in vivo and also ex vivo in serum, lungs, and kidneys using models of genetic ablation coupled with pharmacological inhibitors. In wild-type (WT) mice, infusion of Ang II resulted in a rapid increase of plasma Ang-(1-7). In
Identifiants
pubmed: 31786979
doi: 10.1161/HYPERTENSIONAHA.119.14071
pmc: PMC7286421
mid: NIHMS1549068
doi:
Substances chimiques
Peptide Fragments
0
Angiotensin II
11128-99-7
Angiotensin I
9041-90-1
Carboxypeptidases
EC 3.4.-
Peptidyl-Dipeptidase A
EC 3.4.15.1
lysosomal Pro-X carboxypeptidase
EC 3.4.16.2
Ace2 protein, mouse
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
Prolyl Oligopeptidases
EC 3.4.21.26
angiotensin I (1-7)
IJ3FUK8MOF
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-182Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK080089
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104785
Pays : United States
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