Periodic Nucleation of Calcium Phosphate in a Stirred Biocatalytic Reaction.
biocatalysis
biomineralization
reaction networks
self-organization
systems chemistry
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
received:
03
09
2019
pubmed:
14
12
2019
medline:
9
1
2021
entrez:
14
12
2019
Statut:
ppublish
Résumé
Highly ordered superstructures composed of inorganic nanoparticles appear in natural and synthetic systems, however the mechanisms of non-equilibrium self-organization that may be involved are still poorly understood. Herein, we performed a kinetic investigation of the precipitation of calcium phosphate using a process widely found in microorganisms: the hydrolysis of urea by enzyme urease. With high initial ratio of calcium ion to phosphate, periodic precipitation was obtained accompanied by pH oscillations in a well-stirred, closed reactor. We propose that an internal pH-regulated change in the concentration of phosphate ion is the driving force for periodicity. A simple model involving the biocatalytic reaction network coupled with burst nucleation of nanoparticles above a critical supersaturation reproduced key features of the experiments. These findings may provide insight to the self-organization of nanoparticles in biomineralization and improve design strategies of biomaterials for medical applications.
Identifiants
pubmed: 31833161
doi: 10.1002/anie.201911213
pmc: PMC7027757
doi:
Substances chimiques
Calcium Phosphates
0
Urea
8W8T17847W
calcium phosphate
97Z1WI3NDX
Urease
EC 3.5.1.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2823-2828Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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