Brain-Derived Extracellular Vesicle microRNA Signatures Associated with In Utero and Postnatal Oxycodone Exposure.
Animals
Animals, Newborn
Brain
/ cytology
Cell Communication
Disease Models, Animal
Extracellular Vesicles
/ drug effects
Female
Gene Expression Profiling
/ methods
Gene Expression Regulation, Developmental
/ drug effects
Humans
Male
MicroRNAs
/ genetics
Neurons
/ cytology
Oxycodone
/ adverse effects
Pregnancy
Primary Cell Culture
Rats
Sequence Analysis, RNA
RNA-Seq
brain derived EVs
in utero
oxycodone
postnatal
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
19 12 2019
19 12 2019
Historique:
received:
01
10
2019
revised:
13
12
2019
accepted:
15
12
2019
entrez:
22
12
2019
pubmed:
22
12
2019
medline:
25
8
2020
Statut:
epublish
Résumé
Oxycodone (oxy) is a semi-synthetic opioid commonly used as a pain medication that is also a widely abused prescription drug. While very limited studies have examined the effect of in utero oxy (IUO) exposure on neurodevelopment, a significant gap in knowledge is the effect of IUO compared with postnatal oxy (PNO) exposure on synaptogenesis-a key process in the formation of synapses during brain development-in the exposed offspring. One relatively unexplored form of cell-cell communication associated with brain development in response to IUO and PNO exposure are extracellular vesicles (EVs). EVs are membrane-bound vesicles that serve as carriers of cargo, such as microRNAs (miRNAs). Using RNA-Seq analysis, we identified distinct brain-derived extracellular vesicle (BDEs) miRNA signatures associated with IUO and PNO exposure, including their gene targets, regulating key functional pathways associated with brain development to be more impacted in the IUO offspring. Further treatment of primary 14-day
Identifiants
pubmed: 31861723
pii: cells9010021
doi: 10.3390/cells9010021
pmc: PMC7016745
pii:
doi:
Substances chimiques
MicroRNAs
0
Oxycodone
CD35PMG570
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : R01 DA042379
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS105594
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA049577
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103427
Pays : United States
Déclaration de conflit d'intérêts
All the authors approve the contents presented in the current manuscript and declare no conflicts of interest.
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