The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide.


Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
02 2020
Historique:
received: 25 07 2019
revised: 05 12 2019
pubmed: 22 12 2019
medline: 15 12 2020
entrez: 22 12 2019
Statut: ppublish

Résumé

Fish intake is reported to be associated with certain health benefits; however, accurate assessment of fish intake is still problematic. The objective of this study is to identify fish intake biomarkers and examine relationships with health parameters in a free-living population. In the NutriTech study, ten participants randomized into the fish group consume increasing quantities of fish for 3 days per week for 3 weeks. Urine is analyzed by NMR spectroscopy. Trimethylamine-N-oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose-response with intake (p < 0.05). Fish consumption yields a greater increase in urinary TMAO compared to red meat. Biomarker-derived fish intake is calculated in the National Adult Nutrition Survey cross-sectional study. However, the correlation between fish intake and TMAO (r = 0.148, p < 0.01) and that between fish intake and calculated fish intake (r = 0.142, p < 0.01) are poor. In addition, TMAO shows significantly positive correlation with serum insulin and insulin resistance in males and the relationship is more pronounced for males with high dietary fat intake. Urinary TMAO displays a strong dose-response relationship with fish intake; however, use of TMAO alone is insufficient to determine fish intake in a free-living population.

Identifiants

pubmed: 31863680
doi: 10.1002/mnfr.201900799
doi:

Substances chimiques

Biomarkers 0
Dietary Fats 0
Dimethylamines 0
Insulin 0
Methylamines 0
dimethylamine ARQ8157E0Q
trimethyloxamine FLD0K1SJ1A

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1900799

Informations de copyright

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Xiaofei Yin (X)

UCD School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin, Ireland.

Helena Gibbons (H)

UCD School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin, Ireland.

Milena Rundle (M)

Faculty of Medicine, Department of Medicine, Imperial College London, London, UK.

Gary Frost (G)

Faculty of Medicine, Department of Medicine, Imperial College London, London, UK.

Breige A McNulty (BA)

UCD School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin, Ireland.

Anne P Nugent (AP)

UCD School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin, Ireland.
Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, Northern Ireland.

Janette Walton (J)

School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland.

Albert Flynn (A)

School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.

Lorraine Brennan (L)

UCD School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin, Ireland.

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