Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1.

Alternative Splicing Amino Acid Motifs / genetics Animals COS Cells Cell Cycle / genetics Cell Line, Tumor Cell Nucleus / metabolism Chimerin Proteins / genetics Chlorocebus aethiops Diglycerides / metabolism Exons / genetics Gene Silencing Humans Protein Domains / genetics Protein Isoforms / metabolism RNA, Small Interfering Sequence Deletion rac1 GTP-Binding Protein / genetics
GTPase-activating protein (GAP) Rac (Rac GTPase) cell cycle cell signaling nuclear export signal (NES) nuclear localization nuclear localization signal (NLS) nucleus splicing β1-chimaerin

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
31 01 2020
Historique:
received: 01 04 2019
revised: 14 12 2019
pubmed: 25 12 2019
medline: 15 9 2020
entrez: 25 12 2019
Statut: ppublish

Résumé

β1-chimaerin belongs to the chimaerin family of GTPase-activating proteins (GAPs) and is encoded by the

Identifiants

DOI: 10.1074/jbc.RA119.008688 PMID: 31871052 PMC: PMC6996883
pubmed: 31871052
pii: S0021-9258(17)49887-5
doi: 10.1074/jbc.RA119.008688
pmc: PMC6996883
doi:

Substances chimiques

Chimerin Proteins 0
Diglycerides 0
Protein Isoforms 0
RAC1 protein, human 0
RNA, Small Interfering 0
chimaerin-beta3 protein, human 0
rac1 GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1300-1314

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA189765
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA196232
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026023
Pays : United States

Informations de copyright

© 2020 Casado-Medrano et al.

Références

Mol Biol Rep. 2014;41(4):2067-76
pubmed: 24430297
J Biol Chem. 2007 Feb 23;282(8):5101-5
pubmed: 17170104
Blood. 2011 Jun 9;117(23):6214-26
pubmed: 21474673
Science. 2000 Oct 13;290(5490):333-7
pubmed: 11030651
Hum Mol Genet. 2003 Oct 1;12(19):2449-56
pubmed: 12915445
J Cell Sci. 2010 Jun 1;123(Pt 11):1841-50
pubmed: 20484664
Cancer Cell. 2017 May 8;31(5):621-634.e6
pubmed: 28416184
J Biol Chem. 2009 Jan 2;284(1):478-85
pubmed: 19001369
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10171-6
pubmed: 19520826
FEBS Lett. 2001 Jun 8;498(2-3):157-63
pubmed: 11412848
Int J Mol Med. 2006 Apr;17(4):559-66
pubmed: 16525710
Biochem Soc Trans. 2018 Aug 20;46(4):1003-1012
pubmed: 30065108
J Biol Chem. 2010 Jun 4;285(23):17453-64
pubmed: 20385564
Dev Cell. 2015 Feb 9;32(3):318-34
pubmed: 25640224
Cell. 2012 Jun 22;149(7):1594-606
pubmed: 22726444
PLoS One. 2010 Oct 28;5(10):e15400
pubmed: 21060846
Biochim Biophys Acta. 2011 Sep;1813(9):1562-77
pubmed: 20977914
Cancer Res. 2017 Oct 15;77(20):5445-5451
pubmed: 28807941
Endocrinology. 2000 Jan;141(1):146-52
pubmed: 10614633
EMBO J. 2006 May 17;25(10):2062-74
pubmed: 16628218
J Biol Chem. 1999 Sep 3;274(36):25245-9
pubmed: 10464245
Hum Mol Genet. 1998 May;7(5):919-32
pubmed: 9536098
EMBO J. 2003 Jul 1;22(13):3326-36
pubmed: 12839994
FEBS Lett. 2009 Apr 17;583(8):1237-42
pubmed: 19306875
J Biol Chem. 2008 Dec 26;283(52):36454-64
pubmed: 18974050
J Biol Chem. 1993 Feb 25;268(6):3813-6
pubmed: 8440677
Nat Commun. 2013;4:1849
pubmed: 23673634
Protein Eng Des Sel. 2004 Jun;17(6):527-36
pubmed: 15314210
Trends Biochem Sci. 1999 Jan;24(1):34-6
pubmed: 10087920
Biochem J. 2003 Oct 15;375(Pt 2):313-21
pubmed: 12877655
Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11854-9
pubmed: 10518540
Sci Rep. 2014 Feb 27;4:4219
pubmed: 24573109
J Biol Chem. 1995 Jun 2;270(22):13246-53
pubmed: 7768923
Biochem J. 2008 Feb 15;410(1):167-75
pubmed: 17941827
Mol Cell Biol. 2009 Apr;29(7):1796-813
pubmed: 19158271
Nat Commun. 2017 Nov 24;8(1):1773
pubmed: 29170395
Arch Biochem Biophys. 2004 Sep 1;429(1):23-9
pubmed: 15288806
J Biol Chem. 2008 Jan 18;283(3):1211-5
pubmed: 18024426
Cancer Res. 1995 Aug 1;55(15):3456-61
pubmed: 7614486
Cell. 2004 Oct 29;119(3):407-18
pubmed: 15507211
J Cell Biol. 2008 May 5;181(3):485-96
pubmed: 18443222
J Biol Chem. 1997 Oct 17;272(42):26488-96
pubmed: 9334226
Cell Mol Life Sci. 2009 Feb;66(3):370-4
pubmed: 19151919
J Biol Chem. 2003 Apr 4;278(14):12495-506
pubmed: 12551911
Annu Rev Cell Dev Biol. 1999;15:607-60
pubmed: 10611974
Cell Signal. 2008 Apr;20(4):758-70
pubmed: 18249095
J Comput Biol. 1997 Fall;4(3):311-23
pubmed: 9278062
BMC Bioinformatics. 2009 Jun 29;10:202
pubmed: 19563654
Cancer Cell. 2017 Feb 13;31(2):256-269
pubmed: 28110998
Small GTPases. 2012 Jan-Mar;3(1):60-6
pubmed: 22714419
J Investig Med. 2013 Oct;61(7):1129-31
pubmed: 23941981
J Biol Chem. 2005 Jul 1;280(26):24363-70
pubmed: 15863513
Oncotarget. 2016 May 10;7(19):28301-19
pubmed: 27058424
Biochem Pharmacol. 2000 Nov 15;60(10):1417-24
pubmed: 11020443
PLoS One. 2014 Jul 24;9(7):e102977
pubmed: 25057852
J Cell Biol. 2006 Dec 18;175(6):937-46
pubmed: 17178910
Cell. 2007 Jun 1;129(5):865-77
pubmed: 17540168
Cell. 1995 Jun 16;81(6):917-24
pubmed: 7781068
J Biol Chem. 2001 May 25;276(21):18303-12
pubmed: 11278894
Cancer Res. 2003 May 1;63(9):2284-91
pubmed: 12727851
J Biol Chem. 1994 Apr 29;269(17):12888-92
pubmed: 8175705
J Biol Chem. 2004 Oct 15;279(42):44197-210
pubmed: 15304504
Eur J Biochem. 1995 Feb 1;227(3):636-46
pubmed: 7867622
J Biol Chem. 1995 Sep 15;270(37):21852-9
pubmed: 7665608
Mol Cell Biol. 1996 Sep;16(9):5147-55
pubmed: 8756672
J Cell Sci. 2006 Jan 1;119(Pt 1):141-52
pubmed: 16352660
Traffic. 2010 Feb;11(2):198-209
pubmed: 19961560
Schizophr Res. 2005 Mar 1;73(2-3):383-5
pubmed: 15653288
J Biol Chem. 2002 Feb 8;277(6):4541-50
pubmed: 11689559

Auteurs

Victoria Casado-Medrano (V)

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.
ORCID: 0000-0002-6929-4559

Laura Barrio-Real (L)

Molecular Medicine Unit and Institute of Molecular and Cellular Biology of Cancer, Biomedical Research Institute of Salamanca, University of Salamanca, 37007 Salamanca, Spain.

Laura Gutiérrez-Miranda (L)

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.

Rogelio González-Sarmiento (R)

Molecular Medicine Unit and Institute of Molecular and Cellular Biology of Cancer, Biomedical Research Institute of Salamanca, University of Salamanca, 37007 Salamanca, Spain.
ORCID: 0000-0002-2726-6795

Eladio A Velasco (EA)

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.
ORCID: 0000-0002-9682-5589

Marcelo G Kazanietz (MG)

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

María J Caloca (MJ)

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain mj.caloca@csic.es.
ORCID: 0000-0002-1003-2685

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Motifs d'acides aminés › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules COS › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Chimérines › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Lipides › Glycérides › Diglycéride › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Exons › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Identification of a truncated β1-chimaerin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéines G rac › Protéine G rac1 › Identification of a truncated β1-chimaerin...