Low prevalence of maternal microchimerism in peripheral blood of Japanese children with type 1 diabetes.
Journal
Diabetic medicine : a journal of the British Diabetic Association
ISSN: 1464-5491
Titre abrégé: Diabet Med
Pays: England
ID NLM: 8500858
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
accepted:
19
12
2019
pubmed:
25
12
2019
medline:
30
10
2021
entrez:
25
12
2019
Statut:
ppublish
Résumé
To clarify the prevalence and degree of maternal microchimerism in Japanese children with type 1 diabetes, as well as its effect on phenotypic variation. We studied 153 Japanese children with type 1 diabetes, including 124 children positive for β-cell autoantibodies, and their 71 unaffected siblings. The number of circulating microchimeric cells per 10 Maternal microchimerism was detected in 15% of children with autoantibody-positive type 1 diabetes, 28% of children with autoantibody-negative type 1 diabetes, and 16% of unaffected siblings. There were no differences in the prevalence or levels of maternal microchimerism among the three groups or between the children with type 1 diabetes and their unaffected siblings. Furthermore, maternal microchimerism carriers and non-carriers exhibited similar phenotypes. Maternal microchimerism appears to be less common in Japanese children with type 1 diabetes than in white European people. Our data indicate that maternal microchimerism is unlikely to be a major trigger or a phenotypic determinant of type 1 diabetes in Japanese children and that the biological significance of maternal microchimerism in type 1 diabetes may differ among ethnic groups.
Substances chimiques
Autoantibodies
0
HLA Antigens
0
ICA512 autoantibody
0
SLC30A8 protein, human
0
Zinc Transporter 8
0
anti-GAD65 autoantibody
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2131-2135Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17H06428
Pays : International
Organisme : Japan Agency for Medical Research and Development
ID : 18ek0109278h0002
Pays : International
Organisme : Manpei Suzuki Diabetes Foundation
Pays : International
Organisme : National Center for Child Health and Development
ID : 2019A-1
Pays : International
Organisme : Takeda Foundation
Pays : International
Informations de copyright
© 2019 Diabetes UK.
Références
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