Clinical Influence of Anastomotic Leakage on Esophageal Cancer Survival and Recurrence.
Esophageal cancer
anastomosis leak
overall survival
recurrence
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
15
11
2019
revised:
26
11
2019
accepted:
02
12
2019
entrez:
2
1
2020
pubmed:
2
1
2020
medline:
10
1
2020
Statut:
ppublish
Résumé
We investigated the clinical influence of anastomotic leak (AL) on esophageal cancer survival and recurrence after curative surgery. This study included 122 patients who underwent curative surgery for esophageal cancer between 2008 and 2018. The patients were classified into those with AL and those without. The risk factors for overall (OS) and recurrence-free (RFS) survival were identified. AL was found in 44 out of the 122 patients (36.1%). The respective OS rates at 3 and 5 years after surgery were 43.9% and 40.2% in the AL group and 63.9% and 53.2% in the non-AL group, which were significantly different (p=0.0049). In contrast, the respective RFS rates at 3 and 5 years after surgery were 44.8% and 29.8%, and 44.9% and 42.4%, which were not significantly different (p=0.2306). A multivariate analysis showed that AL was a significant independent risk factor for both poorer OS and RFS in patients who underwent curative surgery for esophageal cancer. To improve survival of patients with esophageal cancer, the surgical procedure, perioperative care and surgical strategy must be carefully planned in order to prevent AL.
Sections du résumé
BACKGROUND
BACKGROUND
We investigated the clinical influence of anastomotic leak (AL) on esophageal cancer survival and recurrence after curative surgery.
PATIENTS AND METHODS
METHODS
This study included 122 patients who underwent curative surgery for esophageal cancer between 2008 and 2018. The patients were classified into those with AL and those without. The risk factors for overall (OS) and recurrence-free (RFS) survival were identified.
RESULTS
RESULTS
AL was found in 44 out of the 122 patients (36.1%). The respective OS rates at 3 and 5 years after surgery were 43.9% and 40.2% in the AL group and 63.9% and 53.2% in the non-AL group, which were significantly different (p=0.0049). In contrast, the respective RFS rates at 3 and 5 years after surgery were 44.8% and 29.8%, and 44.9% and 42.4%, which were not significantly different (p=0.2306). A multivariate analysis showed that AL was a significant independent risk factor for both poorer OS and RFS in patients who underwent curative surgery for esophageal cancer.
CONCLUSION
CONCLUSIONS
To improve survival of patients with esophageal cancer, the surgical procedure, perioperative care and surgical strategy must be carefully planned in order to prevent AL.
Identifiants
pubmed: 31892599
pii: 40/1/443
doi: 10.21873/anticanres.13972
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-449Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.