Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice.
Adenomatous Polyposis Coli Protein
/ genetics
Animals
CD8-Positive T-Lymphocytes
/ immunology
Carcinogenesis
/ drug effects
Colitis
/ chemically induced
Colon
/ drug effects
Colonic Neoplasms
/ genetics
Dendritic Cells
/ immunology
Dextran Sulfate
/ toxicity
Disease Models, Animal
Disease Progression
Fatty Acids, Nonesterified
/ metabolism
Female
Gastrointestinal Microbiome
/ immunology
Humans
Interleukins
/ immunology
Intestinal Mucosa
/ drug effects
Male
Mice
Mice, Knockout
Permeability
Primary Cell Culture
Receptors, G-Protein-Coupled
/ agonists
Cytokine: Cytotoxicity
Microbial Metabolite Receptor
SCFA
Journal
Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
15
02
2019
revised:
14
12
2019
accepted:
18
12
2019
pubmed:
10
1
2020
medline:
11
7
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
Intestinal microbes and their metabolites affect the development of colorectal cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. We investigated the mechanisms by which free fatty acid receptor 2 (FFAR2), a receptor for short-chain fatty acids that can affect the composition of the intestinal microbiome, contributes to the pathogenesis of CRC. We performed studies with Apc Apc Loss of FFAR2 promotes colon tumorigenesis in mice by reducing gut barrier integrity, increasing tumor bacterial load, promoting exhaustion of CD8
Sections du résumé
BACKGROUND & AIMS
Intestinal microbes and their metabolites affect the development of colorectal cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. We investigated the mechanisms by which free fatty acid receptor 2 (FFAR2), a receptor for short-chain fatty acids that can affect the composition of the intestinal microbiome, contributes to the pathogenesis of CRC.
METHODS
We performed studies with Apc
RESULTS
Apc
CONCLUSIONS
Loss of FFAR2 promotes colon tumorigenesis in mice by reducing gut barrier integrity, increasing tumor bacterial load, promoting exhaustion of CD8
Identifiants
pubmed: 31917258
pii: S0016-5085(20)30007-X
doi: 10.1053/j.gastro.2019.12.027
pmc: PMC7291292
mid: NIHMS1589843
pii:
doi:
Substances chimiques
Adenomatous Polyposis Coli Protein
0
Fatty Acids, Nonesterified
0
Ffar2 protein, mouse
0
Il27 protein, mouse
0
Interleukins
0
Receptors, G-Protein-Coupled
0
adenomatous polyposis coli protein, mouse
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1359-1372.e9Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK104927
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK105653
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154426
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020595
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA207021
Pays : United States
Organisme : BLRD VA
ID : I01 BX003382
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK110499
Pays : United States
Organisme : Cancer Research UK
ID : C10674/A27140
Pays : United Kingdom
Informations de copyright
Copyright © 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.
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