Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation-associated renal tumors in Eker rats.
Alleles
Animals
Chromosome Deletion
Chromosomes, Human, Pair 10
/ genetics
Comparative Genomic Hybridization
/ methods
Gamma Rays
/ adverse effects
Heterozygote
Humans
Kidney Neoplasms
/ genetics
Male
Mutation
/ genetics
Rats
Rats, Inbred F344
Rats, Long-Evans
Risk
Tuberous Sclerosis
/ genetics
Tuberous Sclerosis Complex 2 Protein
/ genetics
Tumor Suppressor Proteins
/ genetics
Tsc2
Eker rat
genomic signature
ionizing radiation
renal carcinoma
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
18
07
2019
revised:
23
12
2019
accepted:
31
12
2019
pubmed:
12
1
2020
medline:
17
3
2020
entrez:
12
1
2020
Statut:
ppublish
Résumé
Ionizing radiation can damage DNA and, therefore, is a risk factor for cancer. Eker rats, which carry a heterozygous germline mutation in the tumor-suppressor gene tuberous sclerosis complex 2 (Tsc2), are susceptible to radiation-induced renal carcinogenesis. However, the molecular mechanisms involved in Tsc2 inactivation are unclear. We subjected Fischer 344 × Eker (Long Evans Tsc2
Identifiants
pubmed: 31925975
doi: 10.1111/cas.14307
pmc: PMC7060461
doi:
Substances chimiques
Tsc2 protein, rat
0
Tuberous Sclerosis Complex 2 Protein
0
Tumor Suppressor Proteins
0
Banques de données
GENBANK
['NM_012680.3']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
840-848Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15H01834
Informations de copyright
© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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