Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer's Disease Pathophysiological Hallmarks.
Acetylcholine
/ metabolism
Acetylcholinesterase
Alzheimer Disease
/ drug therapy
Amyloid beta-Peptides
/ chemistry
Antioxidants
/ chemical synthesis
Cell Line
Cholinesterase Inhibitors
/ chemical synthesis
Coumaric Acids
/ chemical synthesis
Glutamic Acid
/ genetics
Humans
Iron
/ metabolism
Mitochondria
/ drug effects
Neurons
/ drug effects
Neuroprotective Agents
/ chemical synthesis
Oxidative Stress
/ drug effects
Protein Aggregation, Pathological
/ drug therapy
Alzheimer disease
cholinesterase inhibitors
excitotoxicity
iron accumulation
mitochondriotropic antioxidants
oxidative stress
β-amyloid
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Jan 2020
09 Jan 2020
Historique:
received:
22
11
2019
revised:
05
01
2020
accepted:
07
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
10
10
2020
Statut:
epublish
Résumé
Alzheimer disease (AD) is the most common neurodegenerative disease featuring progressive and degenerative neurological impairments resulting in memory loss and cognitive decline. The specific mechanisms underlying AD are still poorly understood, but it is suggested that a deficiency in the brain neurotransmitter acetylcholine, the deposition of insoluble aggregates of fibrillar β-amyloid 1-42 (Aβ
Identifiants
pubmed: 31936622
pii: molecules25020276
doi: 10.3390/molecules25020276
pmc: PMC7024345
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Antioxidants
0
Cholinesterase Inhibitors
0
Coumaric Acids
0
Neuroprotective Agents
0
Glutamic Acid
3KX376GY7L
Iron
E1UOL152H7
Acetylcholinesterase
EC 3.1.1.7
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/DTP-FTO/2433/2014, PTDC/BIA-MOL/28607/2017, POCI-01-0145-FEDER-028607
Organisme : European Regional Development Fund
ID : NORTE-01-0145-FEDER-000028
Organisme : Fundação para a Ciência e a Tecnologia
ID : UID/QUI/00081
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