Acquired factor VIII inhibitor in a patient with multiple sclerosis treated with interferon β-1a.
Factor VIII deficiency, acquired
Interferon beta 1a
Multiple sclerosis
Th1 cell
Th2 cell
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 03 2020
15 03 2020
Historique:
received:
19
08
2019
revised:
07
01
2020
accepted:
08
01
2020
pubmed:
17
1
2020
medline:
29
8
2020
entrez:
17
1
2020
Statut:
ppublish
Résumé
Acquired Factor VIII inhibitor is a rare acquired clotting disorder which has been seen in the setting of particular medications, autoimmune disease, and malignancy. Reports of this disorder in patients receiving immunomodulatory therapies for multiple sclerosis are rare. We present a case of a 48 year-old woman with likely development of acquired Factor VIII inhibitor in the setting of interferon beta monotherapy for multiple sclerosis, and discuss the pathogenesis of this disorder which involves shifts in helper T cell populations and increased production of immunoglobulins.
Identifiants
pubmed: 31945592
pii: S0165-5728(19)30404-7
doi: 10.1016/j.jneuroim.2020.577146
pii:
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
Factor VIII
9001-27-8
Interferon beta-1a
XRO4566Q4R
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577146Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.