Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery.
3-Hydroxybutyric Acid
/ blood
Adult
Amino Acids
/ blood
Birth Weight
Body Mass Index
Clostridiales
/ isolation & purification
Creatinine
/ urine
Cresols
/ urine
Enterococcus
/ isolation & purification
Escherichia
/ isolation & purification
Feces
/ microbiology
Female
Fetal Development
Gastric Bypass
Gastrointestinal Microbiome
Gastroplasty
Glutamine
/ analogs & derivatives
Hemiterpenes
/ urine
Humans
Indican
/ urine
Infant, Newborn
/ urine
Insulin Resistance
Isobutyrates
/ blood
Isoleucine
/ blood
Keto Acids
/ urine
Leucine
/ blood
Metabolomics
Micrococcaceae
/ isolation & purification
Phenotype
Phenylacetates
/ urine
Pregnancy
/ blood
Streptococcus
/ isolation & purification
Sulfuric Acid Esters
/ urine
Young Adult
colonic bacteria
colonic fermentation
enteric bacterial microflora
gastric surgery
obesity surgery
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
08
08
2019
revised:
03
12
2019
accepted:
04
12
2019
pubmed:
23
1
2020
medline:
1
4
2021
entrez:
23
1
2020
Statut:
ppublish
Résumé
Due to the global increase in obesity rates and success of bariatric surgery in weight reduction, an increasing number of women now present pregnant with a previous bariatric procedure. This study investigates the extent of bariatric-associated metabolic and gut microbial alterations during pregnancy and their impact on fetal development. A parallel metabonomic (molecular phenotyping based on proton nuclear magnetic resonance spectroscopy) and gut bacterial (16S ribosomal RNA gene amplicon sequencing) profiling approach was used to determine maternal longitudinal phenotypes associated with malabsorptive/mixed (n=25) or restrictive (n=16) procedures, compared with women with similar early pregnancy body mass index but without bariatric surgery (n=70). Metabolic profiles of offspring at birth were also analysed. Previous malabsorptive, but not restrictive, procedures induced significant changes in maternal metabolic pathways involving branched-chain and aromatic amino acids with decreased circulation of leucine, isoleucine and isobutyrate, increased excretion of microbial-associated metabolites of protein putrefaction (phenylacetlyglutamine, Metabolism is altered in pregnant women with a previous malabsorptive bariatric surgery. These alterations may be beneficial for maternal outcomes, but the effect of elevated levels of phenolic and indolic compounds on fetal and infant health should be investigated further.
Identifiants
pubmed: 31964751
pii: gutjnl-2019-319620
doi: 10.1136/gutjnl-2019-319620
pmc: PMC7398482
doi:
Substances chimiques
Amino Acids
0
Cresols
0
Hemiterpenes
0
Isobutyrates
0
Keto Acids
0
Phenylacetates
0
Sulfuric Acid Esters
0
Isoleucine
04Y7590D77
Glutamine
0RH81L854J
4-hydroxyphenylacetic acid
3J9SHG0RCN
4-cresol sulfate
56M34ZQY1S
alpha-ketoisovalerate
759-05-7
isobutyric acid
8LL210O1U0
phenylacetylglutamine
92358I79RG
Creatinine
AYI8EX34EU
Leucine
GMW67QNF9C
Indican
N187WK1Y1J
3-Hydroxybutyric Acid
TZP1275679
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1452-1459Subventions
Organisme : Medical Research Council
ID : MR/P002536/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P028225/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : P62104
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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