Negative supercoil at gene boundaries modulates gene topology.
Chromatin Assembly and Disassembly
DNA Replication
DNA Topoisomerases, Type I
/ metabolism
DNA Topoisomerases, Type II
/ genetics
DNA, Cruciform
/ chemistry
DNA, Fungal
/ chemistry
DNA, Superhelical
/ chemistry
G1 Phase
Gene Expression Regulation, Fungal
Genes, Fungal
High Mobility Group Proteins
/ metabolism
Mutation
Nucleic Acid Hybridization
Nucleosomes
/ chemistry
Open Reading Frames
/ genetics
RNA Polymerase II
/ genetics
RNA, Fungal
/ chemistry
S Phase
Saccharomyces cerevisiae
/ cytology
Saccharomyces cerevisiae Proteins
/ metabolism
Transcription, Genetic
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
30
04
2019
accepted:
25
11
2019
pubmed:
24
1
2020
medline:
6
5
2020
entrez:
24
1
2020
Statut:
ppublish
Résumé
Transcription challenges the integrity of replicating chromosomes by generating topological stress and conflicts with forks
Identifiants
pubmed: 31969709
doi: 10.1038/s41586-020-1934-4
pii: 10.1038/s41586-020-1934-4
doi:
Substances chimiques
DNA, Cruciform
0
DNA, Fungal
0
DNA, Superhelical
0
HMO1 protein, S cerevisiae
0
High Mobility Group Proteins
0
Nucleosomes
0
RNA, Fungal
0
Saccharomyces cerevisiae Proteins
0
TOP2 protein, S cerevisiae
0
RNA Polymerase II
EC 2.7.7.-
TOP1 protein, S cerevisiae
EC 5.99.1.1
DNA Topoisomerases, Type I
EC 5.99.1.2
DNA Topoisomerases, Type II
EC 5.99.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
701-705Références
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