DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m
AlkB Homolog 5, RNA Demethylase
/ metabolism
Animals
Antineoplastic Agents
/ pharmacology
Cell Death
/ drug effects
Cell Line, Tumor
Cisplatin
/ pharmacology
DEAD-box RNA Helicases
/ antagonists & inhibitors
Demethylation
Drug Resistance, Neoplasm
Forkhead Box Protein M1
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Ketorolac Tromethamine
/ pharmacology
Mice
Mouth Neoplasms
/ drug therapy
Nanog Homeobox Protein
/ genetics
Neoplastic Stem Cells
/ drug effects
RNA, Messenger
/ metabolism
Squamous Cell Carcinoma of Head and Neck
/ drug therapy
Tumor Burden
/ drug effects
Xenograft Model Antitumor Assays
ALKBH5
Chemoresistance
Ketorolac
PDX
m6A RNA methylation
Journal
Apoptosis : an international journal on programmed cell death
ISSN: 1573-675X
Titre abrégé: Apoptosis
Pays: Netherlands
ID NLM: 9712129
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
25
1
2020
medline:
9
1
2021
entrez:
25
1
2020
Statut:
ppublish
Résumé
Platinum based drugs alone or in combination with 5FU and docetaxel are common regimen chemotherapeutics for the treatment of advanced OSCC. Chemoresistance is one of the major factors of treatment failure in OSCC. Human RNA helicase DDX3 plays an important role in cell proliferation, invasion, and metastasis in several neoplasms. The potential role of DDX3 in chemoresistance is yet to be explored. Enhanced cancer stem cells (CSCs) population significantly contributes to chemoresistance and recurrence. A recent study showed that m
Identifiants
pubmed: 31974865
doi: 10.1007/s10495-020-01591-8
pii: 10.1007/s10495-020-01591-8
doi:
Substances chimiques
Antineoplastic Agents
0
FOXM1 protein, human
0
Forkhead Box Protein M1
0
NANOG protein, human
0
Nanog Homeobox Protein
0
RNA, Messenger
0
Ketorolac Tromethamine
4EVE5946BQ
ALKBH5 protein, human
EC 1.14.11.-
AlkB Homolog 5, RNA Demethylase
EC 1.14.11.-
DDX3X protein, human
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
233-246Subventions
Organisme : Science and Engineering Research Board
ID : EMR/2015/000063
Pays : International