Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response.
T regulatory cells
graft-versus-host disease
immunosuppression
mesenchymal stem cells
mitochondrial transfer
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
received:
07
03
2019
revised:
11
11
2019
accepted:
29
11
2019
pubmed:
28
1
2020
medline:
28
4
2021
entrez:
28
1
2020
Statut:
ppublish
Résumé
Mesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune-mediated diseases. They exert immunoregulatory and tissue-restoring effects. MSC-mediated transfer of mitochondria (MitoT) has been demonstrated to rescue target organs from tissue damage, yet the mechanism remains to be fully resolved. Therefore, we explored the effect of MitoT on lymphoid cells. Here, we describe dose-dependent MitoT from mitochondria-labeled MSCs mainly to CD4
Identifiants
pubmed: 31984629
doi: 10.15252/embr.201948052
pmc: PMC7001501
doi:
Banques de données
GEO
['GSE140483']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e48052Subventions
Organisme : Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT)
ID : 1170852
Pays : International
Organisme : Consejo Nacional de Innovación, Ciencia y Tecnología, CONICYT)
ID : 15130011
Pays : International
Organisme : Consejo Nacional de Innovación, Ciencia y Tecnología, CONICYT)
ID : PAI79170021
Pays : International
Informations de copyright
© 2020 The Authors.
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