Stabilization of the TAK1 adaptor proteins TAB2 and TAB3 is critical for optimal NF-κB activation.
epitransduction
inflammation
lysosome
proteasome
signalophagy
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
30
12
2019
accepted:
09
01
2020
pubmed:
31
1
2020
medline:
4
5
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
TAB2 and TAB3 bind to K63-linked polyubiquitin chains and recruit the critical kinase MAP3K7 (TAK1). The polyubiquitin-recruited TAK1/TAB2/TAB3 complex comes in close proximity with the IKK (IKKα/IKKβ/IKKγ) complex, which is recruited to M1-linked polyubiquitin chains via the IKKγ (NEMO) component. Together, the two complexes activate the NF-κB family of transcription factors. NF-κB transcription factors are critical mediators of pro-inflammatory signals and must be tightly regulated at multiple levels. Recently, it was discovered that one such point of regulation occurs at the level of TAB2 and TAB3 protein stability by the deubiquitinase USP15. Comment on: https://doi.org/10.1111/febs.15202.
Substances chimiques
Adaptor Proteins, Signal Transducing
0
NF-kappa B
0
Polyubiquitin
120904-94-1
I-kappa B Kinase
EC 2.7.11.10
Banques de données
RefSeq
['NP_001278963.1', 'NP_001090763.1', 'NP_001303622.1', 'XP_007892675.1', 'XP_026690565.1', 'XP_030850455.1', 'XP_002604284.1', 'XP_011448736.1', 'XP_029209972.1', 'NP_690000.3', 'XP_002933854.1', 'NP_001038570.1', 'XP_020386262.1']
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
3161-3164Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2020 Federation of European Biochemical Societies.
Références
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