Evaluation of Financial Conflicts of Interest Among Physician-Authors of American College of Rheumatology Clinical Practice Guidelines.
Arthritis, Rheumatoid
/ drug therapy
Authorship
Conflict of Interest
Databases, Factual
Disclosure
/ standards
Drug Industry
Glucocorticoids
/ adverse effects
Humans
Osteoporosis
/ chemically induced
Physicians
/ statistics & numerical data
Polymyalgia Rheumatica
/ drug therapy
Practice Guidelines as Topic
Rheumatology
Societies, Medical
Spondylarthropathies
/ drug therapy
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
07
02
2019
accepted:
04
02
2020
pubmed:
11
2
2020
medline:
12
1
2021
entrez:
11
2
2020
Statut:
ppublish
Résumé
Clinical practice guidelines (CPGs) underpin patient care, and ideally authors of these guidelines would be free from outside influence. However, it has been shown many times that authors of professional society CPGs receive large sums of money from industry drug companies, creating financial conflicts of interest. This study investigated industry payments catalogued in the Open Payments Database (OPD) that have been received by authors of the American College of Rheumatology (ACR) CPGs. Guidelines on the ACR web site that were published during or after August 2014 were used to retrieve the list of authors. All general, research, associated research, and ownership payments reported on the OPD between the date of publication of the CPG and 12 months prior were extracted in a parallel and blinded manner by 2 investigators. Of the 89 US-based physician-authors from the 5 ACR CPGs identified within the study timeframe, 56 (62.9%) had received at least 1 payment according to OPD records. These 56 authors had received a median of $522 (interquartile range $119-2,500), which, combined, was a total of $9,728,751. Nineteen authors had received at least 1 industry payment relevant to the CPG recommendations, for a median amount of $748 and a total of $1,961,362 in relevant payments. Of the total relevant payments received, a significant proportion was undisclosed (for ACR CPGs during or after August 2014, undisclosed payments were $699,561, or 35.7% of the total). Fewer than one-half of the US-based physician-authors of ACR CPGs during or after August 2014 had received guideline-relevant industry payments. Nonetheless, a substantial proportion of the money received was not disclosed. Conflict of interest disclosure is a bare minimum requirement, and more permanent solutions may include divestiture or inclusion of more nonconflicted authors.
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1427-1434Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020, American College of Rheumatology.
Références
Antonelli M, Coopersmith CM. Professional medical societies: do we have any conflict of interest with industry? Intensive Care Med 2018;44:1762-4.
Grimshaw JM, Russell IT. Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet 1993;342:1317-22.
Checketts JX, Sims MT, Vassar M. Evaluating industry payments among dermatology clinical practice guidelines authors. JAMA Dermatol 2017;153:1229-35.
Checketts JX, Cook C, Vassar M. An evaluation of industry relationships among contributors to AAOS clinical practice guidelines and appropriate use criteria. J Bone Joint Surg Am 2018;100:e10.
Carlisle A, Bowers A, Wayant C, Meyer C, Vassar M. Financial conflicts of interest among authors of urology clinical practice guidelines. Eur Urol 2018;74:348-54.
Horn J, Checketts JX, Jawhar O, Vassar M. Evaluation of industry relationships among authors of otolaryngology clinical practice guidelines. JAMA Otolaryngol Head Neck Surg 2018;144:194-201.
Mitchell AP, Basch EM, Dusetzina SB. Financial relationships with industry among National Comprehensive Cancer Network guideline authors. JAMA Oncol 2016;2:1628-31.
Graham R, Mancher M, Miller Wolman D, Greenfield S, Steinberg E, editors. Clinical practice guidelines we can trust. Washington (DC): National Academies Press; 2011.
American College of Rheumatology. Policy and procedure manual for clinical practice guidelines. January 2015. URL: https://www.rheumatology.org/Portals/0/Files/ACR%20Guideline%20Manual_Appendices_updated%202015.pdf.
Guyatt G, Akl EA, Hirsh J, Kearon C, Crowther M, Gutterman D, et al. The vexing problem of guidelines and conflict of interest: a potential solution. Ann Intern Med 2010;152:738-41.
Kirschner NM, Sulmasy LS, Kesselheim AS. Health policy basics: the Physician Payment Sunshine Act and the Open Payments program. Ann Intern Med 2014;161:519-21.
Wayant C, Turner E, Meyer C, Sinnett P, Vassar M. Financial conflicts of interest among oncologist authors of reports of clinical drug trials. JAMA Oncol 2018;4:1426-8.
Jaiswal D, Checketts JX, Vassar M. Industry payments in cardiology: a cross-sectional analysis of Open Payments data. J Am Osteopath Assoc 2018;118:781-7.
Khan NA, Nguyen CL, Khawar T, Spencer H, Torralba KD. Association of author's financial conflict of interest with characteristics and outcome of rheumatoid arthritis randomized controlled trials. Rheumatology (Oxford) 2019;58:776-85.
Lundh A, Lexchin J, Mintzes B, Schroll JB, Bero L. Industry sponsorship and research outcome. Cochrane Database Syst Rev 2017;2:MR000033.
Centers for Medicare & Medicaid Services. Open Payments. January 2020. URL: https://www.cms.gov/openpayments/.
Combs TR, Scott J, Jorski A, Heavener T, Vassar M. Evaluation of industry relationships among authors of clinical practice guidelines in gastroenterology [letter]. JAMA Intern Med 2018;178:1711-2.
Combs T, Tritz D, Ivy H, von Borstel D, Horn J, Vassar M. Financial conflicts of interest among authors of clinical practice guidelines for routine screening mammography. J Am Coll Radiol 2019;16:1598-603.
Office for Human Research Protections. 45 CFR 46 pre-2018 requirements. URL: https://www.govinfo.gov/content/pkg/CFR-2016-title45-vol1/pdf/CFR-2016-title45-vol1-part46.pdf.
Tibau A, Bedard PL, Srikanthan A, Ethier JL, Vera-Badillo FE, Templeton AJ, et al. Author financial conflicts of interest, industry funding, and clinical practice guidelines for anticancer drugs. J Clin Oncol 2015;33:100-6.
Lo B, Field MJ, editors. Conflict of interest in medical research, education, and practice. Washington (DC): National Academies Press; 2009.
Department of Health and Human Services Office of Inspector General. Open Payments data: review of accuracy, precision, and consistency in reporting; 2018. URL: https://oig.hhs.gov/oei/reports/oei-03-15-00220.pdf.
DeJong C, Aguilar T, Tseng CW, Lin GA, John Boscardin W, Adams Dudley R. Pharmaceutical industry-sponsored meals and physician prescribing patterns for Medicare beneficiaries. JAMA Intern Med 2016;176:1114-22.