Revisiting the Roles of Pro-Metastatic EpCAM in Cancer.
Antigens, Neoplasm
/ metabolism
Biomarkers, Tumor
/ metabolism
Cell Adhesion
/ physiology
Cell Adhesion Molecules
Cell Line, Tumor
Epithelial Cell Adhesion Molecule
/ metabolism
Epithelial-Mesenchymal Transition
Humans
Neoplasm Metastasis
/ physiopathology
Neoplasms
/ metabolism
Neoplastic Cells, Circulating
/ metabolism
Prognosis
adhesion
biomarker
cancer
circulating tumour cell
metastasis
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
30
12
2019
revised:
05
02
2020
accepted:
05
02
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
19
3
2021
Statut:
epublish
Résumé
Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal levels in the basolateral membrane of normal epithelial cells. However, EpCAM expression is upregulated in solid epithelial cancers and stem cells. EpCAM can also be found in disseminated tumour cells and circulating tumour cells. Various OMICs studies have demonstrated that EpCAM plays roles in several key biological processes such as cell adhesion, migration, proliferation and differentiation. Additionally, EpCAM can be detected in the bodily fluid of cancer patients suggesting that EpCAM is a pathophysiologically relevant anti-tumour target as well as being utilized as a diagnostic/prognostic agent for a variety of cancers. This review will focus on the structure-features of EpCAM protein and discuss recent evidence on the pathological and physiological roles of EpCAM in modulating cell adhesion and signalling pathways in cancers as well as deliberating the clinical implication of EpCAM as a therapeutic target.
Identifiants
pubmed: 32046162
pii: biom10020255
doi: 10.3390/biom10020255
pmc: PMC7072682
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Biomarkers, Tumor
0
Cell Adhesion Molecules
0
EPCAM protein, human
0
Epithelial Cell Adhesion Molecule
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Higher Education, Malaysia
ID : FRGS/1/2018/STG04/UKM/03/1
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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