Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 02 2020
Historique:
received: 29 10 2019
accepted: 30 01 2020
entrez: 15 2 2020
pubmed: 15 2 2020
medline: 13 11 2020
Statut: epublish

Résumé

Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. Non-biased RNA sequencing analysis using liver and kidney showed marked activation of gene regulatory pathways associated with the immune system and immune disease in both organs. In accordance, we observed enhanced steatohepatitis with infiltration of inflammatory cells. The investigation of senescence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase in PD-1

Identifiants

pubmed: 32054990
doi: 10.1038/s41598-020-59541-y
pii: 10.1038/s41598-020-59541-y
pmc: PMC7018741
doi:

Substances chimiques

Hyaluronan Receptors 0
Pdcd1 protein, mouse 0
Programmed Cell Death 1 Receptor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2569

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Auteurs

Hitoshi Inokawa (H)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Yasuhiro Umemura (Y)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Akihiro Shimba (A)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.

Eiryo Kawakami (E)

Medical Sciences Innovation Hub Program, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-0856, Japan.

Nobuya Koike (N)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Yoshiki Tsuchiya (Y)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Munehiro Ohashi (M)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Yoichi Minami (Y)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Guangwei Cui (G)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.

Takuma Asahi (T)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.
Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.

Ryutaro Ono (R)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Yuh Sasawaki (Y)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Eiichi Konishi (E)

Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Seung-Hee Yoo (SH)

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX, 77030, USA.

Zheng Chen (Z)

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX, 77030, USA.

Satoshi Teramukai (S)

Department of Biostatistics, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Koichi Ikuta (K)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.

Kazuhiro Yagita (K)

Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. kyagita@koto.kpu-m.ac.jp.

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