Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease.
Adult
Aged
Biomarkers
/ cerebrospinal fluid
Corneal Transplantation
/ adverse effects
Creutzfeldt-Jakob Syndrome
/ cerebrospinal fluid
Dura Mater
/ transplantation
Electroencephalography
Encephalopathy, Bovine Spongiform
/ cerebrospinal fluid
Female
Homozygote
Human Growth Hormone
/ adverse effects
Humans
Iatrogenic Disease
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Methionine
/ genetics
Middle Aged
Neuroimaging
Phenotype
Polymorphism, Genetic
Prion Diseases
/ cerebrospinal fluid
Prion Proteins
/ metabolism
Registries
Reproducibility of Results
Sex Factors
Time Factors
Iatrogenic Creutzfeldt-Jakob disease
RT-QuIC
biomarker
cerebrospinal fluid
corneal transplant
dura matter graft
electroencephalogram
growth hormone
magnetic resonance imaging
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
12 02 2020
12 02 2020
Historique:
received:
11
12
2019
revised:
30
01
2020
accepted:
08
02
2020
entrez:
16
2
2020
pubmed:
16
2
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt-Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.
Identifiants
pubmed: 32059611
pii: biom10020290
doi: 10.3390/biom10020290
pmc: PMC7072321
pii:
doi:
Substances chimiques
Biomarkers
0
Prion Proteins
0
Human Growth Hormone
12629-01-5
Methionine
AE28F7PNPL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : CP/00041
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI19/00144
Pays : International
Organisme : Robert Koch Institute
ID : 1369-341
Pays : International
Organisme : Interreg V-A España-Francia-Andorra
ID : POCTEFA 2014-2020
Pays : International
Organisme : NHMRC Practitioner Fellowship
ID : APP1105784
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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