Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies.
Bacillus subtilis
monoclonal antibodies
nanobody
protein secretion
recombinant-protein production
spores
synthetic biology
Journal
Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
17
12
2019
accepted:
11
02
2020
pubmed:
16
2
2020
medline:
21
10
2020
entrez:
16
2
2020
Statut:
epublish
Résumé
There is a growing need for a highly stable system to allow the production of biologics for diagnoses and therapeutic interventions on demand that could be used in extreme environments. Among the variety of biologics, nanobodies (Nbs) derived from single-chain variable antibody fragments from camelids have attracted great attention in recent years due to their small size and great stability with translational potentials in whole-body imaging and the development of new drugs. Intracellular expression using the bacterium
Identifiants
pubmed: 32060024
pii: AEM.02938-19
doi: 10.1128/AEM.02938-19
pmc: PMC7117931
pii:
doi:
Substances chimiques
Single-Domain Antibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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