Synergistic Activity of Clofazimine and Clarithromycin in an Aerosol Mouse Model of
Aerosols
Animals
Antitubercular Agents
/ administration & dosage
Clarithromycin
/ administration & dosage
Clofazimine
/ pharmacology
Colony Count, Microbial
Drug Synergism
Ethambutol
/ therapeutic use
Female
Lung
/ microbiology
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Mycobacterium avium
/ drug effects
Mycobacterium avium-intracellulare Infection
/ drug therapy
Rifampin
/ therapeutic use
Treatment Outcome
Mycobacterium avium
clofazimine
mouse model
treatment
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
25
11
2019
accepted:
11
02
2020
pubmed:
20
2
2020
medline:
7
4
2021
entrez:
20
2
2020
Statut:
epublish
Résumé
Infections with nontuberculous mycobacteria (NTM) have a poor prognosis in patients with underlying respiratory diseases. Clofazimine (CFZ) showed both experimental and clinical promising results against clinically relevant NTM. However, there are no data on CFZ in combination with the current recommended treatment; therefore, we aimed to study its
Identifiants
pubmed: 32071046
pii: AAC.02349-19
doi: 10.1128/AAC.02349-19
pmc: PMC7179583
pii:
doi:
Substances chimiques
Aerosols
0
Antitubercular Agents
0
Ethambutol
8G167061QZ
Clofazimine
D959AE5USF
Clarithromycin
H1250JIK0A
Rifampin
VJT6J7R4TR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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