Characterization of Adenovirus 5 E1A Exon 1 Deletion Mutants in the Viral Replicative Cycle.
E1A
adenovirus
exon 1
replication
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
14 02 2020
14 02 2020
Historique:
received:
08
01
2020
revised:
10
02
2020
accepted:
12
02
2020
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Human adenovirus infection is driven by Early region 1A (E1A) proteins, which are the first proteins expressed following the delivery of the viral genome to the cellular nucleus. E1A is responsible for reprogramming the infected cell to support virus replication alongside the activation of expression of all viral transcriptional units during the course of the infection. Although E1A has been extensively studied, most of these studies have focused on understanding the conserved region functions outside of a full infection. Here, we investigated the effects of small deletions in E1A exon 1 on the viral replicative cycle. Almost all deletions were found to have a negative impact on viral replication with the exception of one deletion found in the mutant
Identifiants
pubmed: 32075072
pii: v12020213
doi: 10.3390/v12020213
pmc: PMC7077205
pii:
doi:
Substances chimiques
Adenovirus E1A Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-166198
Pays : Canada
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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