The Effect of Ligand Mobility on the Cellular Interaction of Multivalent Nanoparticles.
Angiotensin II
/ chemistry
Animals
Biological Transport
/ drug effects
Cell Line
Chlorpromazine
/ pharmacology
Cytochalasin D
/ pharmacology
Drug Carriers
/ chemistry
Gene Expression
Genistein
/ pharmacology
Kinetics
Ligands
Mesangial Cells
/ cytology
Nanoparticles
/ chemistry
Peptidyl-Dipeptidase A
/ genetics
Polyethylene Glycols
/ chemistry
Protein Binding
Rats
Receptor, Angiotensin, Type 1
/ genetics
cellular interactions
ligand density
ligand mobility
multivalency
polymer nanoparticles
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
16
12
2019
revised:
27
01
2020
pubmed:
23
2
2020
medline:
4
5
2021
entrez:
21
2
2020
Statut:
ppublish
Résumé
Multivalent nanoparticle binding to cells can be of picomolar avidity making such interactions almost as intense as those seen with antibodies. However, reducing nanoparticle design exclusively to avidity optimization by the choice of ligand and its surface density does not sufficiently account for controlling and understanding cell-particle interactions. Cell uptake, for example, is of paramount significance for a plethora of biomedical applications and does not exclusively depend on the intensity of multivalency. In this study, it is shown that the mobility of ligands tethered to particle surfaces has a substantial impact on particle fate upon binding. Nanoparticles carrying angiotensin-II tethered to highly mobile 5 kDa long poly(ethylene glycol) (PEG) chains separated by ligand-free 2 kDa short PEG chains show a superior accumulation in angiotensin-II receptor type 1 positive cells. In contrast, when ligand mobility is constrained by densely packing the nanoparticle surface with 5 kDa PEG chains only, cell uptake decreases by 50%. Remarkably, irrespective of ligand mobility and density both particle types have similar EC50 values in the 1-3 × 10
Identifiants
pubmed: 32077622
doi: 10.1002/mabi.201900427
doi:
Substances chimiques
Agtr1a protein, rat
0
Drug Carriers
0
Ligands
0
Receptor, Angiotensin, Type 1
0
Angiotensin II
11128-99-7
Cytochalasin D
22144-77-0
Polyethylene Glycols
3WJQ0SDW1A
Genistein
DH2M523P0H
Peptidyl-Dipeptidase A
EC 3.4.15.1
Chlorpromazine
U42B7VYA4P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900427Informations de copyright
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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