Eating breakfast and avoiding late-evening snacking sustains lipid oxidation.
Body Mass Index
Breakfast
Carbohydrate Metabolism
/ physiology
Circadian Rhythm
/ physiology
Cross-Over Studies
Feeding Behavior
/ physiology
Female
Humans
Lipid Metabolism
/ physiology
Male
Meals
/ physiology
Middle Aged
Oxidation-Reduction
Pulmonary Gas Exchange
/ physiology
Sleep
/ physiology
Snacks
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
13
11
2019
accepted:
24
01
2020
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
15
5
2020
Statut:
epublish
Résumé
Circadian (daily) regulation of metabolic pathways implies that food may be metabolized differentially over the daily cycle. To test that hypothesis, we monitored the metabolism of older subjects in a whole-room respiratory chamber over two separate 56-h sessions in a random crossover design. In one session, one of the 3 daily meals was presented as breakfast, whereas in the other session, a nutritionally equivalent meal was presented as a late-evening snack. The duration of the overnight fast was the same for both sessions. Whereas the two sessions did not differ in overall energy expenditure, the respiratory exchange ratio (RER) was different during sleep between the two sessions. Unexpectedly, this difference in RER due to daily meal timing was not due to daily differences in physical activity, sleep disruption, or core body temperature (CBT). Rather, we found that the daily timing of nutrient availability coupled with daily/circadian control of metabolism drives a switch in substrate preference such that the late-evening Snack Session resulted in significantly lower lipid oxidation (LO) compared to the Breakfast Session. Therefore, the timing of meals during the day/night cycle affects how ingested food is oxidized or stored in humans, with important implications for optimal eating habits.
Identifiants
pubmed: 32108181
doi: 10.1371/journal.pbio.3000622
pii: PBIOLOGY-D-19-03332
pmc: PMC7046182
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000622Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104497
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124685
Pays : United States
Organisme : NIDDK NIH HHS
ID : P60 DK020593
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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