Coordination of germ layer lineage choice by TET1 during primed pluripotency.
Animals
Cell Differentiation
/ genetics
Cell Lineage
/ genetics
Cells, Cultured
Chromatin
/ metabolism
DNA-Binding Proteins
/ genetics
Embryo, Mammalian
Gene Deletion
Gene Expression Regulation, Developmental
Germ Layers
/ metabolism
Mice
Octamer Transcription Factor-3
/ metabolism
Pluripotent Stem Cells
/ cytology
Proto-Oncogene Proteins
/ genetics
Signal Transduction
/ genetics
Transcription Factors
/ metabolism
cell fate
chromatin accessibility
developmental signaling
epigenetics
germ layer segregation
pluripotency
Journal
Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
10
06
2019
accepted:
27
01
2020
pubmed:
3
3
2020
medline:
18
7
2020
entrez:
3
3
2020
Statut:
ppublish
Résumé
Gastrulation in the early postimplantation stage mammalian embryo begins when epiblast cells ingress to form the primitive streak or develop as the embryonic ectoderm. The DNA dioxygenase Tet1 is highly expressed in the epiblast and yet continues to regulate lineage specification during gastrulation when its expression is diminished. Here, we show how Tet1 plays a pivotal role upstream of germ layer lineage bifurcation. During the transition from naive pluripotency to lineage priming, a global reconfiguration redistributes Tet1 from Oct4-cobound promoters to distal regulatory elements at lineage differentiation genes, which are distinct from high-affinity sites engaged by Oct4. An altered chromatin landscape in
Identifiants
pubmed: 32115407
pii: gad.329474.119
doi: 10.1101/gad.329474.119
pmc: PMC7111260
doi:
Substances chimiques
Chromatin
0
DNA-Binding Proteins
0
Octamer Transcription Factor-3
0
Pou5f1 protein, mouse
0
Proto-Oncogene Proteins
0
TET1 protein, mouse
0
Transcription Factors
0
Zic2 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
598-618Informations de copyright
© 2020 Luo et al.; Published by Cold Spring Harbor Laboratory Press.
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