Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.
Adamantane
/ analogs & derivatives
Animals
Carboxylic Acids
/ chemical synthesis
Cell Line, Tumor
Female
HEK293 Cells
Heterocyclic Compounds, 1-Ring
/ chemical synthesis
Humans
Mice
Molecular Structure
Parasitic Sensitivity Tests
Schistosoma mansoni
/ drug effects
Schistosomiasis mansoni
/ drug therapy
Schistosomicides
/ chemical synthesis
Spiro Compounds
/ chemical synthesis
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
09 04 2020
09 04 2020
Historique:
pubmed:
7
3
2020
medline:
8
10
2020
entrez:
6
3
2020
Statut:
ppublish
Résumé
Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes-another hemoglobin-degrading pathogen. Building on this discovery, we now describe the initial structure-activity relationship (SAR) of antischistosomal ozonide carboxylic acids OZ418 (
Identifiants
pubmed: 32134263
doi: 10.1021/acs.jmedchem.0c00069
pmc: PMC7182039
mid: NIHMS1579713
doi:
Substances chimiques
Carboxylic Acids
0
Heterocyclic Compounds, 1-Ring
0
Schistosomicides
0
Spiro Compounds
0
Adamantane
PJY633525U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3723-3736Subventions
Organisme : NIAID NIH HHS
ID : R01 AI116723
Pays : United States
Références
Bioorg Med Chem Lett. 2005 Nov 15;15(22):4910-4
pubmed: 16169218
Curr Pharm Des. 2012;18(24):3531-8
pubmed: 22607145
Parasitol Res. 2014 Sep;113(9):3259-66
pubmed: 24948106
J Med Chem. 2017 Apr 13;60(7):2654-2668
pubmed: 28052200
PLoS Negl Trop Dis. 2012;6(2):e1474
pubmed: 22348155
ACS Infect Dis. 2016 Jan 8;2(1):54-61
pubmed: 26819968
Anal Chem. 2000 Apr 15;72(8):1781-7
pubmed: 10784141
Science. 1985 May 31;228(4703):1049-55
pubmed: 3887571
J Pharm Sci. 2003 Nov;92(11):2236-48
pubmed: 14603509
Curr Opin Microbiol. 2013 Dec;16(6):722-7
pubmed: 23932203
J Med Chem. 2011 Aug 11;54(15):5540-61
pubmed: 21696174
Antimicrob Agents Chemother. 2007 Aug;51(8):2991-3
pubmed: 17562801
ACS Infect Dis. 2019 Dec 13;5(12):2076-2086
pubmed: 31622078
Parasitol Res. 2014 May;113(5):1769-73
pubmed: 24609234
Acc Chem Res. 2010 Nov 16;43(11):1444-51
pubmed: 20804120
Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1152-1157
pubmed: 28000334
ACS Omega. 2018 Sep 30;3(9):11362-11367
pubmed: 30288462
Nat Commun. 2015 Dec 22;6:10111
pubmed: 26694030
Bioorg Med Chem. 2006 Sep 15;14(18):6368-82
pubmed: 16759871
J Med Chem. 2005 Jul 28;48(15):4953-61
pubmed: 16033274
Parasitol Int. 2018 Apr;67(2):107-111
pubmed: 29081387
Pharmacol Res. 2016 Aug;110:216-226
pubmed: 26902577
Pharm Res. 1997 May;14(5):568-71
pubmed: 9165525
Antimicrob Agents Chemother. 2007 Apr;51(4):1440-5
pubmed: 17283188
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5
pubmed: 21300861
Nat Protoc. 2019 Feb;14(2):461-481
pubmed: 30610241
Angew Chem Int Ed Engl. 2013 Jul 29;52(31):7936-56
pubmed: 23813602
J Med Chem. 2001 Jul 19;44(15):2490-7
pubmed: 11448232
ACS Infect Dis. 2019 Dec 13;5(12):2067-2075
pubmed: 31626733
Nat Med. 2011 Oct 11;17(10):1217-20
pubmed: 21989013
Antimicrob Agents Chemother. 2012 Feb;56(2):1090-2
pubmed: 22106214
Int J Parasitol. 2002 Dec 4;32(13):1655-60
pubmed: 12435450
Angew Chem Int Ed Engl. 2016 May 23;55(22):6401-5
pubmed: 27089538
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7364-7371
pubmed: 27697760
J Org Chem. 2004 Sep 17;69(19):6470-3
pubmed: 15357611
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2481-4
pubmed: 20303754
Infect Dis Poverty. 2017 Mar 28;6(1):74
pubmed: 28351414
Nat Rev Microbiol. 2009 Dec;7(12):864-74
pubmed: 19881520
Antimicrob Agents Chemother. 2008 Apr;52(4):1291-6
pubmed: 18268087