The Mediterranean diet decreases prothrombotic microvesicle release in asymptomatic individuals at high cardiovascular risk.
Aged
Asymptomatic Diseases
Atherosclerosis
/ blood
Biomarkers
/ blood
Blood Platelets
/ metabolism
Cardiovascular Diseases
/ etiology
Cell-Derived Microparticles
Diet, Fat-Restricted
/ methods
Diet, Mediterranean
Dietary Supplements
Female
Heart Disease Risk Factors
Humans
Inflammation Mediators
/ blood
Male
Middle Aged
Nuts
Olive Oil
/ administration & dosage
Thrombosis
/ blood
Cardiovascular disease
Cell activation
Circulating microvesicles
Leukocytes
Mediterranean diet
Platelets
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
05
09
2019
revised:
17
02
2020
accepted:
18
02
2020
pubmed:
10
3
2020
medline:
20
8
2021
entrez:
10
3
2020
Statut:
ppublish
Résumé
Circulating microvesicles (cMV) are small phospholipid-rich vesicles that contribute to the atherothrombotic process, and are biomarkers of cardiovascular disease (CVD) burden and progression. Diet is a cornerstone for CVD prevention, but dietary effects on cMV shedding are poorly characterized. We aimed at assessing the long term effects of a Mediterranean diet compared to a low-fat diet (LFD) on MV shedding by cells of the blood and vascular compartments in patients at high cardiovascular risk treated as per guidelines. A total of 155 participants from the PREDIMED trial free of cardiovascular events after a mean follow-up of 5 years (n = 53 from the Mediterranean diet supplemented with extra-virgin olive oil -EVOO-; n = 49 from the Mediterranean diet supplemented with mixed nuts -Nuts-; and n = 53 from the LFD) were included in the study. At baseline and after one-year intervention, cMV were quantified and characterized by flow cytometry to identify their activated parental cell origin and prothrombotic potential by Annexin V (AV) binding. After one year of dietary intervention, platelet-derived PAC-1 cMV are markers of cell activation and vascular injury that appear to be sensitive to dietary changes. Following a Mediterranean diet rich in EVOO or nuts is associated with lower cell activation towards a pro-atherothrombotic phenotype, suggesting a delay in the development of CV complications.
Sections du résumé
BACKGROUND & AIMS
Circulating microvesicles (cMV) are small phospholipid-rich vesicles that contribute to the atherothrombotic process, and are biomarkers of cardiovascular disease (CVD) burden and progression. Diet is a cornerstone for CVD prevention, but dietary effects on cMV shedding are poorly characterized. We aimed at assessing the long term effects of a Mediterranean diet compared to a low-fat diet (LFD) on MV shedding by cells of the blood and vascular compartments in patients at high cardiovascular risk treated as per guidelines.
METHODS
A total of 155 participants from the PREDIMED trial free of cardiovascular events after a mean follow-up of 5 years (n = 53 from the Mediterranean diet supplemented with extra-virgin olive oil -EVOO-; n = 49 from the Mediterranean diet supplemented with mixed nuts -Nuts-; and n = 53 from the LFD) were included in the study. At baseline and after one-year intervention, cMV were quantified and characterized by flow cytometry to identify their activated parental cell origin and prothrombotic potential by Annexin V (AV) binding.
RESULTS
After one year of dietary intervention, platelet-derived PAC-1
CONCLUSIONS
cMV are markers of cell activation and vascular injury that appear to be sensitive to dietary changes. Following a Mediterranean diet rich in EVOO or nuts is associated with lower cell activation towards a pro-atherothrombotic phenotype, suggesting a delay in the development of CV complications.
Identifiants
pubmed: 32147198
pii: S0261-5614(20)30091-1
doi: 10.1016/j.clnu.2020.02.027
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Olive Oil
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3377-3384Informations de copyright
Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest ER has received research funding through his institution from the California Walnut Commission, has received personal money from this company for the preparation of lectures, and is a nonpaid member of its Scientific Advisory Committee. All other authors declare no competing interests.