Effect of alcohol use on the adolescent brain and behavior.
Adolescent
Adult
Alcoholism
/ psychology
Animals
Attention
/ drug effects
Binge Drinking
/ psychology
Brain
/ drug effects
Cognition
/ drug effects
Ethanol
/ pharmacology
Executive Function
/ drug effects
Female
Humans
Impulsive Behavior
/ drug effects
Male
Memory
/ drug effects
Reward
Underage Drinking
/ psychology
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
04
12
2019
revised:
31
01
2020
accepted:
12
03
2020
pubmed:
18
3
2020
medline:
23
1
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
Adolescence is a particularly vulnerable neurodevelopmental period marked by high rates of engagement with risky alcohol use. This review summarizes the cognitive and neural consequences following alcohol use during adolescence from longitudinal design studies in humans and animals. Findings from human adolescent studies suggest that binge drinking and heavy alcohol use is associated with poorer cognitive functioning on a broad range of neuropsychological assessments, including learning, memory, visuospatial functioning, psychomotor speed, attention, executive functioning, and impulsivity. Alcohol use during adolescence is associated with accelerated decreases in gray matter and attenuated increases in white matter volume, and aberrant neural activity during executive functioning, attentional control, and reward sensitivity tasks, when compared to non-drinking adolescents. Animal studies in rodents and non-human primates have replicated human findings, and suggest cognitive and neural consequences of adolescent alcohol use may persist into adulthood. Novel rodent studies demonstrate that adolescent alcohol use may increase reward responsiveness of the dopamine system to alcohol later in life, as well as disrupt adolescent neurogenesis, potentially through neuroinflammation, with long-lasting neural and behavioral effects into adulthood. Larger longitudinal human cognitive and neuroimaging studies with more diverse samples are currently underway which will improve understanding of the impact of polysubstance use, as well as the interactive effects of substance use, physical and mental health, and demographic factors on cognition and neurodevelopment.
Identifiants
pubmed: 32179028
pii: S0091-3057(19)30602-1
doi: 10.1016/j.pbb.2020.172906
pmc: PMC7183385
mid: NIHMS1578284
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
172906Subventions
Organisme : NIAAA NIH HHS
ID : K23 AA025399
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA027399
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041093
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024635
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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