Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency.
Amidinotransferases
/ deficiency
Amino Acid Metabolism, Inborn Errors
/ metabolism
Animals
Arginine
/ metabolism
Brain
/ metabolism
Creatine
/ metabolism
Developmental Disabilities
/ metabolism
Gene Expression Regulation
/ physiology
Glycine
/ metabolism
Homoarginine
/ metabolism
Intellectual Disability
/ metabolism
Mice
Mice, Inbred C57BL
Speech Disorders
/ metabolism
Stroke
/ metabolism
AGAT
cerebrovascular disease
creatine
gene expression
homoarginine
ischemic stroke
microarray
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Mar 2020
09 Mar 2020
Historique:
received:
03
02
2020
revised:
28
02
2020
accepted:
07
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
l-arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to stroke pathology in both human and mouse studies. However, a comprehensive understanding of the underlying molecular mechanism is lacking. To investigate transcriptional changes in cerebral AGAT metabolism, we applied a transcriptome analysis in brains of wild-type (WT) mice compared to untreated AGAT-deficient (AGAT
Identifiants
pubmed: 32182846
pii: ijms21051865
doi: 10.3390/ijms21051865
pmc: PMC7084559
pii:
doi:
Substances chimiques
Homoarginine
156-86-5
Arginine
94ZLA3W45F
Amidinotransferases
EC 2.1.4.-
glycine amidinotransferase
EC 2.1.4.1
Creatine
MU72812GK0
Glycine
TE7660XO1C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2018_EKES.04
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