Symmetric dimethylarginine values in koalas (Phascolarctos cinereus) based on oxalate nephrosis status.
Phascolarctos cinereus
azotaemia
kidney
koala
oxalate nephrosis
symmetric dimethylarginine
Journal
Australian veterinary journal
ISSN: 1751-0813
Titre abrégé: Aust Vet J
Pays: England
ID NLM: 0370616
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
05
08
2019
revised:
02
02
2020
accepted:
08
02
2020
pubmed:
20
3
2020
medline:
2
7
2020
entrez:
20
3
2020
Statut:
ppublish
Résumé
Oxalate nephrosis is a prevalent renal disease in koalas (Phascolarctos cinereus) of the Mount Lofty Ranges population in South Australia. The symmetric dimethylarginine (SDMA) assay is widely used in companion animals to diagnose renal disease, particularly in the early stages. This study aimed to determine: (1) reference intervals for SDMA in koalas and (2) SDMA values of koalas with oxalate nephrosis. Blood samples were collected from 41 Mount Lofty Ranges koalas euthanased on welfare grounds. Koalas were necropsied and, based on renal histopathology, were classified as unaffected (n = 22) or affected (n = 19) by oxalate nephrosis. Serum or plasma samples were analysed for creatinine, urea and SDMA and urine samples for urine specific gravity (USG). The reference interval for SDMA in unaffected koalas was 2.4-22.9 μg/dL. In koalas with oxalate nephrosis, SDMA was elevated in 74% of cases above the upper limit of the confidence interval. SDMA was elevated in three affected koalas with normal creatinine values. A positive correlation was found between SDMA and creatinine (R = 0.775, P < 0.001) and SDMA and urea (R = 0.580, P < 0.001) and a negative correlation between SDMA and USG (R = -0.495, P = 0.027). In conclusion, SDMA correlates well with other commonly used tests of renal function in koalas and should be included as part of the standard diagnostic process to increase the accuracy of oxalate nephrosis diagnosis in koalas.
Substances chimiques
Oxalates
0
symmetric dimethylarginine
49787G1ULV
Arginine
94ZLA3W45F
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
247-249Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Australian Veterinary Association.
Références
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