Synthesis of indole based acetohydrazide analogs: Their in vitro and in silico thymidine phosphorylase studies.

Dose-Response Relationship, Drug Enzyme Inhibitors / chemical synthesis Escherichia coli / enzymology Hydrazines / chemical synthesis Indoles / chemistry Molecular Docking Simulation Molecular Structure Recombinant Proteins / metabolism Structure-Activity Relationship Thymidine Phosphorylase / antagonists & inhibitors
Acetohydrazide Molecular docking SAR Synthesis Thymidine phosphorylase

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
05 2020
Historique:
received: 07 01 2020
revised: 05 03 2020
accepted: 09 03 2020
pubmed: 23 3 2020
medline: 25 2 2021
entrez: 23 3 2020
Statut: ppublish

Résumé

In this study, a series of indole based acetohydrazide derivatives (1-22) were synthesized and characterized by

Identifiants

DOI: 10.1016/j.bioorg.2020.103745 PMID: 32200327
pubmed: 32200327
pii: S0045-2068(20)30045-6
doi: 10.1016/j.bioorg.2020.103745
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Hydrazines 0
Indoles 0
Recombinant Proteins 0
indole 8724FJW4M5
Thymidine Phosphorylase EC 2.4.2.4
acetylhydrazine SK0DPC9098

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103745

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. Electronic address: mtaha@iau.edu.sa.

Ebaa Ahmed Jassim Aldhamin (EAJ)

College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Noor Barak Almandil (NB)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

El Hassane Anouar (EH)

Department of Chemistry, College of Science and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, Al Kharj 11942, Saudi Arabia.

Nizam Uddin (N)

Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.

Munther Alomari (M)

Department of Stem Cell Biology, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Fazal Rahim (F)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Bushra Adalat (B)

Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Mohamad Ibrahim (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Fasial Nawaz (F)

Department of Chemistry, University of Wah, Quaid Avenue, Wah Cantt 47000, Pakistan.

Naveed Iqbal (N)

Department of Chemistry, University of Poonch Rawalakot AJK, Pakistan.

Bandar Alghanem (B)

Medical Research Core Facility and Platforms (MRCFP), King Abdullah International Medical Research Center/ King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Medical City (KAMC), NGHA, Riyadh 11426, Saudi Arabia.

Abdulelah Altolayyan (A)

Medical Research Core Facility and Platforms (MRCFP), King Abdullah International Medical Research Center/ King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Medical City (KAMC), NGHA, Riyadh 11426, Saudi Arabia.

Khalid Mohammed Khan (KM)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Articles similaires

Decoding the genomic terrain: functional insights into 14 chemosensory proteins in whitefly Bemisia tabaci Asia II-1.

M N Rudra Gouda, Sabtharishi Subramanian
1.00
Animals Hemiptera Insect Proteins Phylogeny Insecticides

Drug repurposing against fucosyltransferase-2 via docking, STD-NMR, and molecular dynamic simulation studies.

Muhammad Atif, Humaira Zafar, Atia-Tul- Wahab et al.
1.00
Fucosyltransferases Drug Repositioning Molecular Docking Simulation Molecular Dynamics Simulation Humans

Bioinspired gelated cell sheet-supported lactobacillus biofilm for aerobic vaginitis diagnosis and treatment.

Yueyue Gui, Qingfei Sun, Kexin Li et al.
1.00
Female Biofilms Animals Lactobacillus Mice

A head-to-head comparison of MM/PBSA and MM/GBSA in predicting binding affinities for the CB

Mei Qian Yau, Clarence W Y Liew, Jing Hen Toh et al.
1.00
Receptor, Cannabinoid, CB1 Ligands Molecular Dynamics Simulation Protein Binding Thermodynamics

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis of indole based acetohydrazide...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes mineurs d'histocompatibilité › Thymidine phosphorylase › Synthesis of indole based acetohydrazide...