Why Is AUG the Start Codon?: Theoretical Minimal RNA Rings: Maximizing Coded Information Biases 1st Codon for the Universal Initiation Codon AUG.
origins of life
ribosomal RNA
simulation
teleonomy
translation
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
26
10
2019
revised:
09
02
2020
pubmed:
1
4
2020
medline:
19
8
2021
entrez:
1
4
2020
Statut:
ppublish
Résumé
The rational design of theoretical minimal RNA rings predetermines AUG as the universal start codon. This design maximizes coded amino acid diversity over minimal sequence length, defining in silico theoretical minimal RNA rings, candidate ancestral genes. RNA rings code for 21 amino acids and a stop codon after three consecutive translation rounds, and form a degradation-delaying stem-loop hairpin. Twenty-five RNA rings match these constraints, ten start with the universal initiation codon AUG. No first codon bias exists among remaining RNA rings. RNA ring design predetermines AUG as initiation codon. This is the only explanation yet for AUG as start codon. RNA ring design determines additional RNA ring gene- and tRNA-like properties described previously, because it presumably mimics constraints on life's primordial RNAs.
Identifiants
pubmed: 32227358
doi: 10.1002/bies.201900201
doi:
Substances chimiques
Codon
0
Codon, Initiator
0
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900201Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 WILEY Periodicals, Inc.
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