KLF4
Animals
Cell Line, Tumor
Cell Proliferation
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Hypoxia
/ genetics
Hypoxia-Inducible Factor 1, alpha Subunit
/ drug effects
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors
/ drug effects
Mechanistic Target of Rapamycin Complex 1
/ antagonists & inhibitors
Meningeal Neoplasms
/ genetics
Meningioma
/ genetics
Mice
Mice, Nude
Mutation
Neoplasm Transplantation
Prolyl Hydroxylases
Protein Kinase Inhibitors
/ pharmacology
RNA-Seq
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Sirolimus
/ analogs & derivatives
Skull Base Neoplasms
Tumor Hypoxia
/ genetics
Up-Regulation
Edema
HIF
Hypoxia
K409Q
KLF4
Meningioma
Mutation
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
03 04 2020
03 04 2020
Historique:
received:
14
01
2020
accepted:
09
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
16
1
2021
Statut:
epublish
Résumé
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base meningiomas triggers a distinct tumor phenotype. Transcriptomic analysis of 17 meningioma samples revealed that KLF4
Identifiants
pubmed: 32245394
doi: 10.1186/s40478-020-00912-x
pii: 10.1186/s40478-020-00912-x
pmc: PMC7118946
doi:
Substances chimiques
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
KLF4 protein, human
0
Klf4 protein, mouse
0
Kruppel-Like Factor 4
0
Kruppel-Like Transcription Factors
0
Protein Kinase Inhibitors
0
temsirolimus
624KN6GM2T
Prolyl Hydroxylases
EC 1.14.11.-
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
41Subventions
Organisme : Deutsche Krebshilfe
ID : 70112956
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : MA2530/6-1
Pays : International
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