COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?
ADAM17 Protein
/ antagonists & inhibitors
Angiotensin-Converting Enzyme 2
Betacoronavirus
/ drug effects
COVID-19
China
Coronavirus Infections
/ drug therapy
Disease Progression
Furin
/ metabolism
Heart Arrest
/ etiology
Heart Diseases
/ drug therapy
Heart Failure
/ etiology
Humans
Interleukin-6
/ immunology
Lung Diseases
/ drug therapy
Myocarditis
/ etiology
Pandemics
Peptidyl-Dipeptidase A
/ deficiency
Pneumonia, Viral
/ drug therapy
Receptors, Notch
/ antagonists & inhibitors
SARS-CoV-2
Signal Transduction
/ drug effects
ADAM17
Angiotensin-converting enzyme 2
COVID-19
Cardiovascular disease
Coronavirus disease
Furin
Notch
Journal
Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342
Informations de publication
Date de publication:
09 04 2020
09 04 2020
Historique:
received:
21
03
2020
accepted:
30
03
2020
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.
Identifiants
pubmed: 32274570
doi: 10.1007/s00395-020-0791-5
pii: 10.1007/s00395-020-0791-5
pmc: PMC7144545
doi:
Substances chimiques
Interleukin-6
0
Receptors, Notch
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Furin
EC 3.4.21.75
ADAM17 Protein
EC 3.4.24.86
ADAM17 protein, human
EC 3.4.24.86
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
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