Antimutagenic effect of an Asclepias subulata extract against heterocyclic aromatic amines commonly found in cooked meat and its heat stability.
Antimutagenicity
Cardenolides
Heterocyclic aromatic amines
Meat
Phytochemicals
Thermal stability
Journal
Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639
Informations de publication
Date de publication:
30 Aug 2020
30 Aug 2020
Historique:
received:
18
10
2019
revised:
21
03
2020
accepted:
31
03
2020
pubmed:
14
4
2020
medline:
21
7
2020
entrez:
14
4
2020
Statut:
ppublish
Résumé
The antimutagenicity of an extract from the medicinal plant Asclepias subulata (ASE) against heterocyclic aromatic amines (HAAs) commonly found in cooked meat, as well as its stability to heat treatment (HT), was evaluated. HT (180 °C/3 min) had no effect on the content in ASE of the bioactive compound corotoxigenin-3-O-glucopyranoside; conversely, calotropin significantly decreased by 72%. ASE exerted antimutagenicity against PhIP, MelQ, and MelQx in TA98 and TA100 Salmonella strains, and this activity was not affected by heat, with the exception of MelQ (p < 0.05). Since HAAs can induce colorectal cancer, the thermal stability of ASE's antiproliferative effect against colorectal cancer cells was also evaluated. HT decreased (p < 0.05) the antiproliferative activity of ASE; however, the remaining activity was still strong with an IC
Identifiants
pubmed: 32283373
pii: S0308-8146(20)30587-2
doi: 10.1016/j.foodchem.2020.126725
pii:
doi:
Substances chimiques
Amines
0
Antimutagenic Agents
0
Carcinogens
0
Heterocyclic Compounds
0
Imidazoles
0
Plant Extracts
0
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
909C6UN66T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126725Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.