Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
Flo11 flocculin
S. cerevisiae
biofilm
cell adhesion
kin discrimination
molecular biophysics
structural biology
yeast
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
received:
31
01
2020
accepted:
03
04
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Microorganisms have evolved specific cell surface molecules that enable discrimination between cells from the same and from a different kind. Here, we investigate the role of Flo11-type cell surface adhesins from social yeasts in kin discrimination. We measure the adhesion forces mediated by Flo11A-type domains using single-cell force spectroscopy, quantify Flo11A-based cell aggregation in populations and determine the Flo11A-dependent segregation of competing yeast strains in biofilms. We find that Flo11A domains from diverse yeast species confer remarkably strong adhesion forces by establishing homotypic interactions between single cells, leading to efficient cell aggregation and biofilm formation in homogenous populations. Heterotypic interactions between Flo11A domains from different yeast species or
Identifiants
pubmed: 32286952
doi: 10.7554/eLife.55587
pii: 55587
pmc: PMC7156268
doi:
pii:
Substances chimiques
FLO11 protein, S cerevisiae
0
Membrane Glycoproteins
0
Saccharomyces cerevisiae Proteins
0
Banques de données
PDB
['5FV5', '5FV6']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 987
Informations de copyright
© 2020, Brückner et al.
Déclaration de conflit d'intérêts
SB, RS, TK, RH, DH, EJ, KD, DM, LO, HM No competing interests declared
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