Comorbid argyrophilic grain disease in an 87-year-old male with spinocerebellar ataxia type 31 with dementia: a case report.
Argyrophilic grain disease
Autopsy
Case report
Spinocerebellar ataxia type 31
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
15 Apr 2020
15 Apr 2020
Historique:
received:
03
12
2019
accepted:
12
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Spinocerebellar ataxia type 31 (SCA31) is not usually associated with dementia, and autopsy in a patient with both conditions is very rare. An 87-year-old male patient presented with ataxia and progressive dementia. Genetic testing led to a diagnosis of SCA31. Fifteen years after his initial symptoms of hearing loss and difficulty walking, he died of aspiration pneumonia. A pathological analysis showed cerebellar degeneration consistent with SCA31 and abundant argyrophilic grains in the hippocampal formation and amygdala that could explain his dementia. This is the first autopsy report on comorbid argyrophilic grain disease with SCA31.
Sections du résumé
BACKGROUND
BACKGROUND
Spinocerebellar ataxia type 31 (SCA31) is not usually associated with dementia, and autopsy in a patient with both conditions is very rare.
CASE PRESENTATION
METHODS
An 87-year-old male patient presented with ataxia and progressive dementia. Genetic testing led to a diagnosis of SCA31. Fifteen years after his initial symptoms of hearing loss and difficulty walking, he died of aspiration pneumonia. A pathological analysis showed cerebellar degeneration consistent with SCA31 and abundant argyrophilic grains in the hippocampal formation and amygdala that could explain his dementia.
CONCLUSIONS
CONCLUSIONS
This is the first autopsy report on comorbid argyrophilic grain disease with SCA31.
Identifiants
pubmed: 32293309
doi: 10.1186/s12883-020-01723-2
pii: 10.1186/s12883-020-01723-2
pmc: PMC7158122
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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