Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids.
Bisindole
Hydrazone
Molecular docking
Synthesis
β-Glucuronidase inhibition
Journal
Molecular diversity
ISSN: 1573-501X
Titre abrégé: Mol Divers
Pays: Netherlands
ID NLM: 9516534
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
29
01
2020
accepted:
03
04
2020
pubmed:
18
4
2020
medline:
23
11
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
The β-glucuronidase, a lysosomal enzyme, catalyzes the cleavage of glucuronosyl-O-bonds. Its inhibitors play a significant role in different medicinal therapies as they cause a decrease in carcinogen-induced colonic tumors by reducing the level of toxic substances present in the intestine. Among those inhibitors, bisindole derivatives had displayed promising β-glucuronidase inhibition activity. In the current study, hydrazone derivatives of bisindolymethane (1-30) were synthesized and evaluated for in vitro β-glucuronidase inhibitory activity. Twenty-eight analogs demonstrated better activity (IC
Identifiants
pubmed: 32301032
doi: 10.1007/s11030-020-10084-4
pii: 10.1007/s11030-020-10084-4
doi:
Substances chimiques
Glycoproteins
0
Hydrazones
0
Indoles
0
beta-glucuronidase inhibitor
0
Glucuronidase
EC 3.2.1.31
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
995-1009Subventions
Organisme : Kementerian Pendidikan Malaysia
ID : 600-IRMI/FRGS 5/3 (111/2019)
Organisme : Kementerian Pendidikan Malaysia
ID : 600-RMI/FRGS 5/3 (0065/2016)
Organisme : Universiti Teknologi MARA (MY)
ID : 600-IRMI/PERDANA 5/3 BESTARI (041/2018)
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