Late drug-resistance in mild MTLE: Can it be influenced by preexisting white matter alterations?
Adult
Anticonvulsants
/ therapeutic use
Brain
/ diagnostic imaging
Diffusion Magnetic Resonance Imaging
Drug Resistance
Drug Resistant Epilepsy
/ diagnostic imaging
Epilepsy, Temporal Lobe
/ drug therapy
Female
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Neuroimaging
White Matter
/ diagnostic imaging
drug-resistance
hippocampal sclerosis
long-term outcome of epilepsy
onset of drug resistance
structural MRI alterations
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
22
01
2020
revised:
21
03
2020
accepted:
23
03
2020
pubmed:
21
4
2020
medline:
1
12
2020
entrez:
21
4
2020
Statut:
ppublish
Résumé
To identify early structural alterations preceding the development of drug-resistance in mild mesial temporal lobe epilepsy (mMTLE), a drug-responsive syndrome ideal for investigating epilepsy pathophysiology and potential prognostic markers of long-term clinical outcome, using magnetic resonance imaging (MRI) at baseline and after 12-year follow-up. Since 2002, a total of 55 participants with a baseline diagnosis of mMTLE underwent three-dimensional (3D) T1 1.5T MRI. Based on long-term outcome (follow-up 12 ± 3 years), we identified 39 patients with stable mMTLE (smMTLE) and 16 patients who had developed drug-resistance overtime (refractory MTLE [rMTLE]). At follow-up, 21 smMTLE and 13 rMTLE patients underwent 3T-MRI including diffusion-weighted scans. Structural images were processed using longitudinal voxel-based morphometry and standard Freesurfer analysis. Statistical analyses were carried out accounting for age, age at onset, gender, hippocampal volume, and hippocampal sclerosis (Hs). Patients presented similar demographic, clinical, and Hs features. White matter volume of the arcuate fasciculi, corticospinal tracts, left retrosplenial cingulum, and left inferior longitudinal fasciculus was reduced only in rMTLE patients before the development of drug-resistance. At follow-up, rMTLE showed decreased fractional anisotropy in the corpus callosum, superior longitudinal fasciculi, and major bundles of the right hemisphere. White matter temporal and extratemporal abnormalities are preexisting in patients with mild MTLE who will develop drug-resistance, independently from the presence of Hs. Thus, these changes might be due to an inherited genetic alteration rather than a subordinate worsening after repeated seizures, multiple antiepileptic drugs, or initial precipitating factors.
Substances chimiques
Anticonvulsants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
924-934Informations de copyright
© 2020 International League Against Epilepsy.
Références
Labate A, Gambardella A, Andermann E, Aguglia U, Cendes F, Berkovic SF, et al. Benign mesial temporal lobe epilepsy. Nat Rev Neurol. 2011;7:237-40.
Labate A, Cerasa A, Gambardella A, Aguglia U, Quattrone A. Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study. Neurology. 2008;71:1094-101.
Labate A, Aguglia U, Tripepi G, Mumoli L, Ferlazzo E, Baggetta R, et al. Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study. Neurology. 2016;86:1904-10.
Labate A, Cherubini A, Tripepi G, Mumoli L, Ferlazzo E, Aguglia U, et al. White matter abnormalities differentiate severe from benign temporal lobe epilepsy. Epilepsia. 2015;56:1109-16.
Caligiuri ME, Labate A, Cherubini A, Mumoli L, Ferlazzo E, Aguglia U, et al. Integrity of the corpus callosum in patients with benign temporal lobe epilepsy. Epilepsia. 2016;57:590-6.
Labate A, Ventura P, Gambardella A, Le Piane E, Colosimo E, Leggio U, et al. MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy. Neurology. 2006;66:562-5.
Gambardella A, Labate A, Colosimo E, Ambrosio R, Quattrone A. Monotherapy for partial epilepsy: focus on levetiracetam. Neuropsychiatr Dis Treat. 2008;4:33-8.
Engel J Jr. Update on surgical treatment of the epilepsies: Summary of The Second International Palm Desert Conference on the Surgical Treatment of the Epilepsies (1992). Neurology. 1993;43(8):1612-7.
Aguglia U, Gambardella A, Le Piane E, Messina D, Oliveri RL, Russo C et al Mild non-lesional temporal lobe epilepsy. A common, unrecognized disorder with onset in adulthood. Can J Neurol Sci. 1998;25:282-6.
Gambardella A, Manna I, Labate A, Chifari R, La Russa A, Serra P, et al. GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. Neurology. 2003;60:560-3.
Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010;51:1069-77.
Vasta R, Caligiuri ME, Labate A, Cherubini A, Mumoli L, Ferlazzo E, et al. 3-T magnetic resonance imaging simultaneous automated multimodal approach improves detection of ambiguous visual hippocampal sclerosis. Eur J Neurol. 2015;22:725-e47.
Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. Fsl. Neuroimage. 2012;62:782-90.
Fischl B. FreeSurfer. Neuroimage. 2012;62:774-81.
Douaud G, Smith S, Jenkinson M, Behrens T, Johansen-Berg H, Vickers J, et al. Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. Brain. 2007;130:2375-86.
Dell'Oglio E, Ceccarelli A, Glanz BI, Healy BC, Tauhid S, Arora A, et al. Quantification of global cerebral atrophy in multiple sclerosis from 3T MRI using SPM: the role of misclassification errors. J Neuroimaging. 2015;25:191-9.
Whelan CD, Altmann A, Botía JA, Jahanshad N, Hibar DP, Absil J, et al. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study. Brain. 2018;141:391-408.
Douaud G, Mackay C, Andersson J, James S, Quested D, Ray MK, et al. Schizophrenia delays and alters maturation of the brain in adolescence. Brain. 2009;132:2437-48.
Menke RA, Körner S, Filippini N, Douaud G, Knight S, Talbot K, et al. Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis. Brain. 2014;137:2546-55.
Behrens TE, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, Clare S, et al. Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magn Reson Med. 2003;50:1077-88.
Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage. 2006;31:1487-505.
Patenaude B, Smith SM, Kennedy DN, Jenkinson M. A Bayesian model of shape and appearance for subcortical brain segmentation. NeuroImage. 2011;56:907-22.
Smith SM, Zhang Y, Jenkinson M, Chen J, Matthews PM, Federico A, et al. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. NeuroImage. 2002;17:479-89.
Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. NeuroImage. 2014;92:381-97.
Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ et al Epilepsy biomarkers. Epilepsia. 2013;54(Suppl 4):61-9.
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K et al Advances in the development of biomarkers for epilepsy. Lancet Neurol. 2016;15:843-856.
Concha L, Kim H, Bernasconi A, Bernhardt BC, Bernasconi N. Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. Neurology. 2012;79:455-62.
Chiang MC, Barysheva M, Shattuck DW, Lee AD, Madsen SK, Avedissian C, et al. Genetics of brain fiber architecture and intellectual performance. Version 2. J Neurosci. 2009;29:2212-24.
Gambardella A, Labate A. Imaging genetics for benign mesial temporal lobe epilepsy. In: Bernasconi A, Bernasconi N, Koepp M, editors. Imaging biomarkers in epilepsy. Cambridge: Cambridge University Press, 2019; p. 48-54.
Vaughan DN, Raffelt D, Curwood E, Tsai MH, Tournier JD, Connelly A, et al. Tract-specific atrophy in focal epilepsy: Disease, genetics, or seizures? Ann Neurol. 2017;81:240-50.
Whelan CD, Alhusaini S, O'Hanlon E, Cheung M, Iyer PM, Meaney JF, et al. White matter alterations in patients with MRI-negative temporal lobe epilepsy and their asymptomatic siblings. Epilepsia. 2015;56:1551-61.
Alhusaini S, Whelan CD, Sisodiya SM, Thompson PM. Quantitative magnetic resonance imaging traits as endophenotypes for genetic mapping in epilepsy. Neuroimage Clin. 2016;12:526-34.
Powell HW, Parker GJ, Alexander DC, Symms MR, Boulby PA, Wheeler-Kingshott CA, et al. Abnormalities of language networks in temporal lobe epilepsy. NeuroImage. 2007;36:209-21.
Shon YM, Kim YI, Koo BB, Lee JM, Kim HJ, Kim WJ, et al. Group-specific regional white matter abnormality revealed in diffusion tensor imaging of medial temporal lobe epilepsy without hippocampal sclerosis. Epilepsia. 2010;51:529-35.
Pell GS, Briellmann RS, Pardoe H, Abbott DF, Jackson GD. Composite voxel-based analysis of volume and T2 relaxometry in temporal lobe epilepsy. NeuroImage. 2008;39:1151-61.