Acetylcholine Muscarinic M

Acetylcholine Alcoholism / drug therapy Animals Cholinergic Agents Humans Rats Receptor, Muscarinic M4 / genetics Rodentia
Acetylcholine Alcohol Caudate-putamen Dorsal striatum Muscarinic Relapse

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
15 12 2020
Historique:
received: 15 11 2019
revised: 03 02 2020
accepted: 19 02 2020
pubmed: 26 4 2020
medline: 9 3 2021
entrez: 26 4 2020
Statut: ppublish

Résumé

Alcohol use disorder (AUD) is a major socioeconomic burden on society, and current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and seeking alters frontostriatal function. We performed genome-wide RNA sequencing and subsequent quantitative polymerase chain reaction and receptor binding validation in the caudate-putamen of human AUD samples to identify potential therapeutic targets. We then back-translated our top candidate targets into a rodent model of long-term alcohol consumption to assess concordance of molecular adaptations in the rat striatum. Finally, we adopted rat behavioral models of alcohol intake and seeking to validate a potential therapeutic target. We found that G protein-coupled receptors were the top canonical pathway differentially regulated in individuals with AUD. The M Collectively, these results identify the M

Sections du résumé

BACKGROUND
Alcohol use disorder (AUD) is a major socioeconomic burden on society, and current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and seeking alters frontostriatal function.
METHODS
We performed genome-wide RNA sequencing and subsequent quantitative polymerase chain reaction and receptor binding validation in the caudate-putamen of human AUD samples to identify potential therapeutic targets. We then back-translated our top candidate targets into a rodent model of long-term alcohol consumption to assess concordance of molecular adaptations in the rat striatum. Finally, we adopted rat behavioral models of alcohol intake and seeking to validate a potential therapeutic target.
RESULTS
We found that G protein-coupled receptors were the top canonical pathway differentially regulated in individuals with AUD. The M
CONCLUSIONS
Collectively, these results identify the M

Identifiants

DOI: 10.1016/j.biopsych.2020.02.019 PMID: 32331824
pubmed: 32331824
pii: S0006-3223(20)30131-1
doi: 10.1016/j.biopsych.2020.02.019
pii:
doi:

Substances chimiques

Cholinergic Agents 0
Receptor, Muscarinic M4 0
Acetylcholine N9YNS0M02X

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

898-909

Subventions

Organisme : NIAAA NIH HHS
ID : R28 AA012725
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Leigh C Walker (LC)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

Alice E Berizzi (AE)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Nicola A Chen (NA)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

Patricia Rueda (P)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Victoria M Perreau (VM)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

Katherine Huckstep (K)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

Jirawoot Srisontiyakul (J)

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand.

Piyarat Govitrapong (P)

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand.

Jia Xiaojian (J)

Shenzhen Kangning Hospital, Shenzhen University Health Science Center, Shenzhen, China; Shenzhen Mental Health Center, Shenzhen University Health Science Center, Shenzhen, China.

Craig W Lindsley (CW)

Department of Pharmacology, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee; Department of Chemistry, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee.

Carrie K Jones (CK)

Department of Pharmacology, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee; Department of Chemistry, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee.

Darren M Riddy (DM)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Arthur Christopoulos (A)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Christopher J Langmead (CJ)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: chris.langmead@monash.edu.

Andrew J Lawrence (AJ)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia. Electronic address: andrew.lawrence@florey.edu.au.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Acetylcholine Muscarinic M
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Alcoolisme › Acetylcholine Muscarinic M
questionsmedicales.fr › Eucaryotes › Animaux › Acetylcholine Muscarinic M
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Acetylcholine Muscarinic M
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acetylcholine Muscarinic M
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Acetylcholine Muscarinic M
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M4 › Acetylcholine Muscarinic M
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Acetylcholine Muscarinic M