Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G.
Animals
Apoptosis
/ immunology
Carrier Proteins
/ genetics
Cells, Cultured
Coculture Techniques
Gene Knockdown Techniques
Growth Hormone
/ deficiency
H-2 Antigens
/ genetics
HLA-G Antigens
/ genetics
Hepatectomy
Hepatocytes
Humans
Immunity, Innate
Killer Cells, Natural
/ immunology
Liver
/ physiology
Liver Regeneration
/ immunology
Macrophages
/ immunology
Mice
Natural Killer T-Cells
/ immunology
Primary Cell Culture
Recombinant Proteins
/ genetics
Signal Transduction
/ genetics
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
01
02
2020
revised:
06
04
2020
accepted:
07
04
2020
pubmed:
29
4
2020
medline:
10
8
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains. PHx was performed on C57BL/6 mice lacking GHR (Ghr GH induction of H2-Bl expression is crucial for reducing innate immune-mediated apoptosis and promoting survival after PHx in C57BL/6 mice. Treatment with HLA-G may lead to improved clinical outcomes following liver surgery or transplantation.
Sections du résumé
BACKGROUND AND AIMS
Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains.
APPROACH AND RESULTS
PHx was performed on C57BL/6 mice lacking GHR (Ghr
CONCLUSIONS
GH induction of H2-Bl expression is crucial for reducing innate immune-mediated apoptosis and promoting survival after PHx in C57BL/6 mice. Treatment with HLA-G may lead to improved clinical outcomes following liver surgery or transplantation.
Identifiants
pubmed: 32342533
doi: 10.1002/hep.31297
pmc: PMC7894545
pii: 01515467-202102000-00022
doi:
Substances chimiques
Carrier Proteins
0
H-2 Antigens
0
HLA-G Antigens
0
Recombinant Proteins
0
Growth Hormone
9002-72-6
somatotropin-binding protein
W06KFL3RDT
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
759-775Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 The Authors. Hepatology published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.
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