The biological activities, molecular docking studies, and anticancer effects of 1-arylsuphonylpyrazole derivatives.

Molecular Docking Simulation Structure-Activity Relationship
Pyrazolpiridines anticancer enzyme inhibition molecular docking pyridazole pyridines

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
Jun 2021
Historique:
pubmed: 5 5 2020
medline: 3 7 2021
entrez: 5 5 2020
Statut: ppublish

Résumé

This work is devoted to definition of the direction of reaction between 1-benzenesulfonylimino pyridinium chloride and α- or β-halo-containing sulfamides, chloroacetic acid, 1-chloro-2,3-dihydroxypropane, etc. The optimal conditions for the synchronous reaction of heterocyclization are determined. Benzenesulfonyliminopyridinium chloride was obtained to form pyrazolopyridines with 1,2-polarophiles, and pyridazine pyridines with 1,3-polarophiles. These novel derivatives were found as effective inhibitors of the α-glycosidase with K

Identifiants

DOI: 10.1080/07391102.2020.1763838 PMID: 32364008
pubmed: 32364008
doi: 10.1080/07391102.2020.1763838
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3336-3346

Auteurs

Parham Taslimi (P)

Faculty of Science, Department of Biotechnology, Bartin University, Bartin, Turkey.
ORCID: 0000-0002-3171-0633

Yavuz Erden (Y)

Faculty of Science, Department of Molecular Biology and Genetics, Bartin University, Bartin, Turkey.

Sabir Mamedov (S)

Laboratory of Faine Organic Synthesis, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, Baku, Azerbaijan.

Lala Zeynalova (L)

Laboratory of Faine Organic Synthesis, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, Baku, Azerbaijan.

Nina Ladokhina (N)

Laboratory of Faine Organic Synthesis, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, Baku, Azerbaijan.

Recep Tas (R)

Faculty of Science, Department of Biotechnology, Bartin University, Bartin, Turkey.

Burak Tuzun (B)

Faculty of Sciences, Department of Chemistry, Cumhuriyet University, Sivas, Turkey.

Afsun Sujayev (A)

Laboratory of Faine Organic Synthesis, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, Baku, Azerbaijan.

Nastaran Sadeghian (N)

Faculty of Sciences, Department of Chemistry, Ataturk University, Erzurum, Turkey.

Saleh H Alwasel (SH)

Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

Ilhami Gulcin (I)

Faculty of Sciences, Department of Chemistry, Ataturk University, Erzurum, Turkey.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › The biological activities, molecular docking...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › The biological activities, molecular docking...