Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates.

Allopurinol / pharmacology Catalysis Dose-Response Relationship, Drug Flavonoids / pharmacology Mercaptopurine / chemistry Oxidation-Reduction / drug effects Xanthine / chemistry Xanthine Oxidase / chemistry
6-mercaptopurine biotransformation flavonoid conjugates flavonoids food-drug interaction xanthine xanthine oxidase

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 May 2020
Historique:
received: 23 03 2020
revised: 21 04 2020
accepted: 04 05 2020
entrez: 9 5 2020
pubmed: 10 5 2020
medline: 9 2 2021
Statut: epublish

Résumé

Flavonoids are natural phenolic compounds, which are the active ingredients in several dietary supplements. It is well-known that some flavonoid aglycones are potent inhibitors of the xanthine oxidase (XO)-catalyzed uric acid formation

Identifiants

DOI: 10.3390/ijms21093256 PMID: 32380641 PMC: PMC7246923
pubmed: 32380641
pii: ijms21093256
doi: 10.3390/ijms21093256
pmc: PMC7246923
pii:
doi:

Substances chimiques

Flavonoids 0
Xanthine 1AVZ07U9S7
Allopurinol 63CZ7GJN5I
Mercaptopurine E7WED276I5
Xanthine Oxidase EC 1.17.3.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Social Fund
ID : EFOP-3.6.1.-16-2016-00004

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Auteurs

Violetta Mohos (V)

Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
ORCID: 0000-0001-6248-060X

Eszter Fliszár-Nyúl (E)

Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.

Miklós Poór (M)

Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Allopurinol › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Mercaptopurine › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Xanthine › Inhibition of Xanthine Oxidase-Catalyzed...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Xanthine oxidase › Inhibition of Xanthine Oxidase-Catalyzed...