The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts Treg/Th17 Cell Balance through Interleukin 6.
Adenosine
/ analogs & derivatives
Adenosine A2 Receptor Agonists
/ pharmacology
Animals
Disease Models, Animal
Female
Fracture Healing
/ drug effects
Interleukin-6
/ immunology
Phenethylamines
/ pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Adenosine A2A
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Th17 Cells
/ immunology
Tibial Fractures
/ drug therapy
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
12
2019
revised:
01
04
2020
accepted:
03
04
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
12
2
2021
Statut:
epublish
Résumé
The aim of this study was to explore the effect of adenosine A2A receptor agonists on fracture healing and the regulation of the immunity system after bone fracture. We implanted fibrin gel containing adenosine A2A receptor agonist CGS 21680/inhibitor ZM 241385/saline locally in rat tibial fracture models, finding that the adenosine A2A receptor agonist could promote fracture healing. At the same time, the adenosine A2A receptor agonist decreased the level of IL-6 in blood and the fracture area, increased Treg cells, and decreased Th17 cells in blood of bone fracture rats. Further, tibial fracture rats implanted with the adenosine A2A receptor agonist gel were injected with IL-6. We found that IL-6 could reverse the effect of adenosine A2A receptor agonists on fracture healing and Treg/Th17 cells in blood. Through the above results, we believe that the adenosine A2A receptor agonist can promote fracture healing and regulate Treg/Th17 cells in blood of rats with fractures. These effects are related to IL-6.
Identifiants
pubmed: 32382539
doi: 10.1155/2020/2603873
pmc: PMC7195650
doi:
Substances chimiques
Adenosine A2 Receptor Agonists
0
Il6 protein, rat
0
Interleukin-6
0
Phenethylamines
0
Receptor, Adenosine A2A
0
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
120225-54-9
Adenosine
K72T3FS567
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2603873Informations de copyright
Copyright © 2020 Xi Zheng and Dong Wang.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
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