Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration.
Adult
Alcohol Deterrents
/ pharmacology
Alcohol-Related Disorders
/ diagnostic imaging
Aldehyde Dehydrogenase 1 Family
/ genetics
Aldehyde Dehydrogenase, Mitochondrial
/ genetics
Central Nervous System Depressants
/ administration & dosage
Cues
Ethanol
/ administration & dosage
Female
Functional Neuroimaging
Genotype
Gyrus Cinguli
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Multilevel Analysis
Naltrexone
/ pharmacology
Proportional Hazards Models
Random Allocation
Receptors, Opioid, mu
/ genetics
Self Administration
Thalamus
/ diagnostic imaging
Ventral Striatum
/ diagnostic imaging
Young Adult
Alcohol Self-administration
Cue-Induced Craving
Human Laboratory
Neuroimaging
Ventral Striatum
Journal
Alcoholism, clinical and experimental research
ISSN: 1530-0277
Titre abrégé: Alcohol Clin Exp Res
Pays: England
ID NLM: 7707242
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
01
01
2020
revised:
07
04
2020
accepted:
08
04
2020
pubmed:
15
5
2020
medline:
15
12
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
Human laboratory paradigms are a pillar in medication development for alcohol use disorders (AUD). Neuroimaging paradigms, in which individuals are exposed to cues that elicit neural correlates of alcohol craving (e.g., mesocorticolimbic activation), are increasingly utilized to test the effects of AUD medications. Elucidation of the translational effects of these neuroimaging paradigms on human laboratory paradigms, such as self-administration, is warranted. The current study is a secondary analysis examining whether alcohol cue-induced activation in the ventral striatum is predictive of subsequent alcohol self-administration in the laboratory. Non-treatment-seeking heavy drinkers of East Asian descent (n = 41) completed a randomized, placebo-controlled, double-blind, crossover experiment on the effects of naltrexone on neuroimaging and human laboratory paradigms. Participants completed 5 days of study medication (or placebo); on day 4, they completed a neuroimaging alcohol taste cue-reactivity task. On the following day (day 5), participants completed a 60-minute alcohol self-administration paradigm. Multilevel Cox regressions indicated a significant effect of taste cue-elicited ventral striatum activation on latency to first drink, Wald χ Neuroimaging alcohol taste cue paradigms may be predictive of laboratory paradigms such as self-administration. Elucidation of the relationships among different paradigms will inform how these paradigms may be used synergistically in experimental medicine and medication development.
Sections du résumé
BACKGROUND
Human laboratory paradigms are a pillar in medication development for alcohol use disorders (AUD). Neuroimaging paradigms, in which individuals are exposed to cues that elicit neural correlates of alcohol craving (e.g., mesocorticolimbic activation), are increasingly utilized to test the effects of AUD medications. Elucidation of the translational effects of these neuroimaging paradigms on human laboratory paradigms, such as self-administration, is warranted. The current study is a secondary analysis examining whether alcohol cue-induced activation in the ventral striatum is predictive of subsequent alcohol self-administration in the laboratory.
METHODS
Non-treatment-seeking heavy drinkers of East Asian descent (n = 41) completed a randomized, placebo-controlled, double-blind, crossover experiment on the effects of naltrexone on neuroimaging and human laboratory paradigms. Participants completed 5 days of study medication (or placebo); on day 4, they completed a neuroimaging alcohol taste cue-reactivity task. On the following day (day 5), participants completed a 60-minute alcohol self-administration paradigm.
RESULTS
Multilevel Cox regressions indicated a significant effect of taste cue-elicited ventral striatum activation on latency to first drink, Wald χ
CONCLUSIONS
Neuroimaging alcohol taste cue paradigms may be predictive of laboratory paradigms such as self-administration. Elucidation of the relationships among different paradigms will inform how these paradigms may be used synergistically in experimental medicine and medication development.
Identifiants
pubmed: 32406553
doi: 10.1111/acer.14342
pmc: PMC7336863
mid: NIHMS1597505
doi:
Substances chimiques
Alcohol Deterrents
0
Central Nervous System Depressants
0
OPRM1 protein, human
0
Receptors, Opioid, mu
0
Ethanol
3K9958V90M
Naltrexone
5S6W795CQM
Aldehyde Dehydrogenase 1 Family
EC 1.2.1
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224-1233Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR033176
Pays : United States
Organisme : NIAAA NIH HHS
ID : F32 AA027699
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024635
Pays : United States
Organisme : UCLA Clinical and Translational Science Institute
ID : UL1RR033176
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA025704
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026190
Pays : United States
Organisme : UCLA Clinical and Translational Science Institute
ID : UL1TR000124
Pays : International
Organisme : NIAAA NIH HHS
ID : R01 AA021744
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01AA021744
Pays : United States
Informations de copyright
© 2020 by the Research Society on Alcoholism.
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