Blood urea in preterm infants on routine parenteral nutrition: A multiple linear regression analysis.
Amino Acids
/ analysis
Birth Weight
Creatinine
/ blood
Ductus Arteriosus, Patent
/ physiopathology
Eating
/ physiology
Female
Gestational Age
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature
/ blood
Infant, Small for Gestational Age
/ blood
Linear Models
Male
Multivariate Analysis
Parenteral Nutrition
Respiratory Distress Syndrome, Newborn
/ physiopathology
Urea
/ blood
Amino acid
Blood urea
Parenteral nutrition
Preterm infants
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
12
11
2019
revised:
22
04
2020
accepted:
26
04
2020
pubmed:
20
5
2020
medline:
18
8
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
Blood urea is considered a marker of amino acid utilization in preterm infants on routine parenteral nutrition. However, the association between blood urea and intravenous amino acid intake remains debated. To evaluate the association between blood urea and both nutrition and clinical data, in a large cohort of preterm infants. Consecutively admitted preterm infants with a gestational age of less than 32 weeks and a birth weight lower than 1250 g on routine parenteral nutrition from the first hour of life were studied. Clinical and nutrition data collected hourly during the hospitalization were used in multiple linear regression analysis. We studied 674 patients and 1863 blood urea determinations. Blood urea concentration was positively associated with blood creatinine concentration, intravenous amino acid intake, patent ductus arteriosus and respiratory distress syndrome, and negatively associated with intravenous non-protein energy intakes, daily weight change, gestational age, being small for gestational age, antenatal steroids therapy and reverse flow in the umbilical artery (p < 0.001; R = 0.7). From a nutrition perspective, in our large cohort of small preterm infants blood urea was positively correlated with intravenous amino acid intake and negatively correlated with intravenous non-protein energy intake. This is in line with current knowledge in human physiology and suggest that a reduction of intravenous amino acid intake based on blood urea concentrations was justified.
Sections du résumé
BACKGROUND
Blood urea is considered a marker of amino acid utilization in preterm infants on routine parenteral nutrition. However, the association between blood urea and intravenous amino acid intake remains debated.
AIMS
To evaluate the association between blood urea and both nutrition and clinical data, in a large cohort of preterm infants.
METHODS
Consecutively admitted preterm infants with a gestational age of less than 32 weeks and a birth weight lower than 1250 g on routine parenteral nutrition from the first hour of life were studied. Clinical and nutrition data collected hourly during the hospitalization were used in multiple linear regression analysis.
RESULTS
We studied 674 patients and 1863 blood urea determinations. Blood urea concentration was positively associated with blood creatinine concentration, intravenous amino acid intake, patent ductus arteriosus and respiratory distress syndrome, and negatively associated with intravenous non-protein energy intakes, daily weight change, gestational age, being small for gestational age, antenatal steroids therapy and reverse flow in the umbilical artery (p < 0.001; R = 0.7).
CONCLUSIONS
From a nutrition perspective, in our large cohort of small preterm infants blood urea was positively correlated with intravenous amino acid intake and negatively correlated with intravenous non-protein energy intake. This is in line with current knowledge in human physiology and suggest that a reduction of intravenous amino acid intake based on blood urea concentrations was justified.
Identifiants
pubmed: 32423698
pii: S0261-5614(20)30213-2
doi: 10.1016/j.clnu.2020.04.039
pii:
doi:
Substances chimiques
Amino Acids
0
Urea
8W8T17847W
Creatinine
AYI8EX34EU
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
153-156Informations de copyright
Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors report no conflicts of interest.