Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma.
Animals
Apoptosis
Benzamides
/ pharmacology
Biomarkers, Tumor
/ genetics
Cell Proliferation
Cyclin-Dependent Kinase 4
/ antagonists & inhibitors
Cyclin-Dependent Kinase 6
/ antagonists & inhibitors
Diphenylamine
/ analogs & derivatives
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
MAP Kinase Kinase 1
/ antagonists & inhibitors
Melanoma
/ drug therapy
Mice
Mice, Nude
Oxidative Phosphorylation
Oxygen Consumption
Protein Kinase Inhibitors
/ pharmacology
Pyridones
/ pharmacology
Pyrimidinones
/ pharmacology
Transcriptome
/ drug effects
Tumor Cells, Cultured
Uveal Neoplasms
/ drug therapy
Xenograft Model Antitumor Assays
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
25
10
2019
revised:
19
03
2020
accepted:
15
05
2020
pubmed:
21
5
2020
medline:
3
6
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Frequent
Identifiants
pubmed: 32430489
pii: 1535-7163.MCT-19-1016
doi: 10.1158/1535-7163.MCT-19-1016
pmc: PMC7415561
mid: NIHMS1597331
doi:
Substances chimiques
Benzamides
0
Biomarkers, Tumor
0
Protein Kinase Inhibitors
0
Pyridones
0
Pyrimidinones
0
trametinib
33E86K87QN
mirdametinib
86K0J5AK6M
Diphenylamine
9N3CBB0BIQ
CDK4 protein, human
EC 2.7.11.22
CDK6 protein, human
EC 2.7.11.22
Cyclin-Dependent Kinase 4
EC 2.7.11.22
Cyclin-Dependent Kinase 6
EC 2.7.11.22
MAP Kinase Kinase 1
EC 2.7.12.2
MAP2K1 protein, human
EC 2.7.12.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1719-1726Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA182635
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009666
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
J Transl Med. 2017 Jun 23;15(1):145
pubmed: 28645290
Cell. 2010 Apr 2;141(1):69-80
pubmed: 20371346
J Clin Oncol. 2017 Nov 10;35(32):3638-3646
pubmed: 28968163
Cancer Res. 2015 Mar 15;75(6):930-9
pubmed: 25627977
Nature. 2009 Jan 29;457(7229):599-602
pubmed: 19078957
Cell Rep. 2016 Feb 9;14(5):979-990
pubmed: 26804906
Cancer Res. 2014 Dec 1;74(23):7037-47
pubmed: 25297634
J Clin Oncol. 2018 Apr 20;36(12):1232-1239
pubmed: 29528792
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
N Engl J Med. 2016 Nov 17;375(20):1925-1936
pubmed: 27959613
JAMA Ophthalmol. 2016 Jul 1;134(7):728-33
pubmed: 27123562
Mol Cancer Res. 2017 May;15(5):501-506
pubmed: 28223438
Cancer Cell. 2014 Jun 16;25(6):822-30
pubmed: 24882516
N Engl J Med. 2010 Dec 2;363(23):2191-9
pubmed: 21083380
Cancer Discov. 2018 May;8(5):568-581
pubmed: 29496664
Clin Cancer Res. 2019 Nov 1;25(21):6429-6442
pubmed: 31439581
JAMA. 2014 Jun 18;311(23):2397-405
pubmed: 24938562
Cancer Cell. 2017 Aug 14;32(2):204-220.e15
pubmed: 28810145
Arch Ophthalmol. 2001 May;119(5):670-6
pubmed: 11346394
Genome Biol. 2014;15(12):550
pubmed: 25516281
Mol Oncol. 2016 Jan;10(1):73-84
pubmed: 26365896
Lancet Oncol. 2015 Jan;16(1):25-35
pubmed: 25524798
Clin Sci (Lond). 2018 Mar 9;132(5):543-568
pubmed: 29523752
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Cancer Cell. 2013 Mar 18;23(3):302-15
pubmed: 23477830
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
Mol Cancer Res. 2019 Apr;17(4):963-973
pubmed: 30567972
Curr Opin Oncol. 2015 Mar;27(2):141-50
pubmed: 25588041
Cancer Res. 2015 Jul 1;75(13):2737-48
pubmed: 25952648
Cancer Res. 2016 Sep 15;76(18):5455-66
pubmed: 27488531
EMBO Mol Med. 2019 Feb;11(2):
pubmed: 30610113
Nat Med. 2012 Oct;18(10):1503-10
pubmed: 22983396
Pigment Cell Melanoma Res. 2014 Mar;27(2):297-308
pubmed: 24354797
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Oncotarget. 2018 May 18;9(38):24980-24991
pubmed: 29861847
Mol Cancer Ther. 2017 Mar;16(3):516-528
pubmed: 28138035
Sci Transl Med. 2019 May 8;11(491):
pubmed: 31068440
Curr Opin Pharmacol. 2005 Aug;5(4):350-6
pubmed: 15955734
Cancer Cell. 2013 Mar 18;23(3):287-301
pubmed: 23416000