The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction-An Animal Experimental Study.
Alveolar Bone Loss
/ etiology
Animals
Bone Density Conservation Agents
/ administration & dosage
Bone Regeneration
Models, Anatomic
Pamidronate
/ administration & dosage
Postoperative Complications
/ prevention & control
Random Allocation
Swine
Swine, Miniature
Tooth Extraction
/ adverse effects
Tooth Socket
/ pathology
bisphosphonates
bone regeneration
bone remodeling
pamidronate
ridge preservation
socket preservation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 May 2020
20 May 2020
Historique:
received:
19
04
2020
revised:
13
05
2020
accepted:
18
05
2020
entrez:
24
5
2020
pubmed:
24
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM Inspect 2018 (GOM, Braunschweig). After 16 weeks, the lower jaws were prepared and examined using standard histological methods. In the test group (BEGO OSS + pamidronate), buccooral dimensional loss was significantly lower, both vestibulary (0.80 ± 0.57 mm vs. 1.92 ± 0.63 mm;
Identifiants
pubmed: 32443867
pii: ijms21103616
doi: 10.3390/ijms21103616
pmc: PMC7279330
pii:
doi:
Substances chimiques
Bone Density Conservation Agents
0
Pamidronate
OYY3447OMC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BEGO Implant Systems GmbH & Co. KG, Bremen, Germany
ID : 1103/103
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
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